2011 Fiscal Year Final Research Report
Cardiovascular protective effect of sedation against invasive stress caused by dental care
| Project/Area Number |
21592576
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OSHITA Shuzo 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (60144945)
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| Co-Investigator(Renkei-kenkyūsha) |
KAWANO Takashi 高知大学, 教育研究部医療学系臨床医学部門, 講師 (40380076)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 精神鎮静法 / イオンチャネル |
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| Research Abstract |
In cultured rat pheochromocytoma cells(PC12), membrane potential was measured using the cell membrane voltage-sensitive fluorescent dye. Midazolam intravenous anesthetic, did not reach to detect a significant change in activity of the cell membrane ATP-sensitive potassium channels. Furthermore, spinal nerves ligation injury model(SNL model) that was one of the chronic animal pain models with a rat was made, and the adrenal chromaffin cell was isolated and extracted. However, that failed to get a measurable cell enough.
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