2011 Fiscal Year Final Research Report
Effects of intravenous sedation on higher brain function and development of new intravenous sedatives
| Project/Area Number |
21592580
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Tsurumi University (2010-2011)
Kyushu Dental College (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAHARA Yukie 久留米大学, 医学部, 講師 (10279135)
HARANO Nozomu 九州歯科大学, 歯学部, 助教 (50423976)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯科麻酔学 / ストレス / 抗不安薬 / 鎮静薬 / 静脈内鎮静法 / マイクロダイアリシス / 中枢神経系 / ラット |
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| Research Abstract |
We studied effects of the acute stress on monoamine neural activity in the rat brain The actions of the anxiolytis and sedatives on the central nervous system have been studied by microdialysis. This approach has shown that anxiolytis and sedatives suppress the accentuation of the locus coeruleus-medial prefrontal cortex noradrenaline neural activity, the accentuation of the ventral tegmental area-nucleus accumbens dopamine neuron activity, and the accentuation of the raphe-amygdala serotonin neuron activity in the stress state.
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Research Products
(11 results)
