2011 Fiscal Year Final Research Report
Elucidation and suppression of the orthodontically induced root resorption in patients with allergic condition
| Project/Area Number |
21592600
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
IOI Hideki 九州大学, 大学病院 (10274474)
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| Co-Investigator(Kenkyū-buntansha) |
KIDO Mizuho 九州大学, 歯学研究院, 准教授 (60253457)
TAKAHASHI Ichirou 九州大学, 歯学研究院, 教授 (70241643)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯学 / 矯正 / 歯根吸収 |
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| Research Abstract |
In the present study, we investigated the effects of allergies on tooth movement and bone and tooth root resorption. Tooth root resorption were increased in ovalbumin(OVA)-sensitized rats subjected to orthodontic force for 24 hours. The expression levels of cytokines such as TNF-α, IL-1β, IL-6 were increased in OVA-sensitized rats, compared with non-sensitized rats. Furthermore, LT expression and the mRNA expression levels of 5-lipoxygenase were also upregulated. Aspirin suppressed tooth root resorption and the cytokines productions.
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