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2011 Fiscal Year Final Research Report

Analysis of SHIP related to osteoclastogenesis

Research Project

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Project/Area Number 21592606
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNagasaki University

Principal Investigator

YOSHIMATSU Masako  長崎大学, 病院, 助教 (20420630)

Co-Investigator(Kenkyū-buntansha) KITAURA Hideki  東北大学, 病院, 講師 (60295087)
YOSHIDA Noriaki  長崎大学, 大学院・医歯薬学総合研究科, 教授 (40230750)
Co-Investigator(Renkei-kenkyūsha) FUJIMURA Yuji  長崎大学, 大学院・医歯薬学総合研究科, 助教 (70448504)
Project Period (FY) 2009 – 2011
KeywordsSHIP / TNF-α / 破骨細胞 / 矯正歯科
Research Abstract

SH2-containing inositol-5'-phosphatase(SHIP), which is related to immunoreaction, has been reported to negatively regulate the proliferation of osteoclast precursors induced by macrophage colony-stimulating factor(M-CSF) and ligand for receptor activator of nuclear factor kappa B(RANKL). In this study, we investigated the effects of SHIP on TNF-α-induced osteoclastogenesis. Bone marrow cells from SHIP+/+ and SHIP-/-mice were cultured with M-CSF and TNF-α. The number of TRAP-positive cells was significantly increased in SHIP-/-cells compared with SHIP+/+ cells. These results suggest that SHIP may negatively regulate the proliferation of osteoclast precursors.

  • Research Products

    (31 results)

All 2012 2011 2010 2009 Other

All Journal Article (14 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Inhibitory effects of IL-12 on experimental tooth movement and root resorption in mice2012

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
    • Journal Title

      Arch Oral Biol

      Volume: 57(1) Pages: 36-43

  • [Journal Article] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo2012

    • Author(s)
      Kimura K, Kitaura H, Fujii T, Hakami ZW, Takano-Yamamoto T
    • Journal Title

      FEMS Immunol Med Microbio

      Volume: 64(2) Pages: 219-227

  • [Journal Article] IL-12-and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells2011

    • Author(s)
      Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
    • Journal Title

      Calcif Tissue Int

      Volume: 89(1) Pages: 65-73

  • [Journal Article] IFN-γdirectly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/ Fas ligand interactions2011

    • Author(s)
      Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Masuyama R, Yoshida N
    • Journal Title

      Immunol Lett

      Volume: 30(137) Pages: 53-61

  • [Journal Article] Tooth movement and root resorption ; The effect of ovariectomy on orthodontic force application in rats.2011

    • Author(s)
      Sirisoontorn I, Hotokezaka H, Hashimoto M, Gonzales C, Luppanapornlarp S, Darendeliler MA, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 81(4) Pages: 570-577

  • [Journal Article] Effects of fluoride intake on orthodontic tooth movement and orthodontically induced root resorption2011

    • Author(s)
      Gonzales C, Hotokezaka H, Karadeniz EI, Miyazaki T, Kobayashi E, Darendeliler MA, Yoshida N
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 139(2) Pages: 196-205

  • [Journal Article] IL-18 inhibits TNF-alpha-induced osteoclastogenesis possibly via a T cell-independent mechanism in synergy with IL-12 in vivo2010

    • Author(s)
      Morita Y, Kitaura H, Yoshimatsu M, Fujimura Y, Kohara H, Eguchi T, Yoshida N
    • Journal Title

      Calcif Tissue Int

      Volume: 86(3) Pages: 242-248

  • [Journal Article] Repair of root resorption 2 to 16 weeks after the application of continuous forces on maxillary first molars in rats : a 2-and 3-dimensional quantitative evaluation2010

    • Author(s)
      Gonzales C, Hotokezaka H, Darendeliler MA, Yoshida N
    • Journal Title

      Am J Orthod Dentofacial Orthop

      Volume: 137(4) Pages: 477-485

  • [Journal Article] IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivo2009

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Eguchi T, Kohara H, Morita Y, Yoshida N
    • Journal Title

      Bone

      Volume: 45(5) Pages: 1010-1016

  • [Journal Article] Influence of bisphosphonates on orthodontic tooth movement in mice2009

    • Author(s)
      Fujimura Y, Kitaura H, Yoshimatsu M, Eguchi T, Kohara H, Morita Y, Yoshida N
    • Journal Title

      Eur J Orthod

      Volume: 31(6) Pages: 572-577

  • [Journal Article] An M-CSF receptor c-Fms antibody inhibits mechanical stress-induced root resorption during orthodontic tooth movement in mice2009

    • Author(s)
      Kitaura H, Fujimura Y, Yoshimatsu M, Eguchi T, Kohara H, Jang I, Morita Y, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 79(5) Pages: 835-841

  • [Journal Article] An in vivo 3D micro-CT evaluation of tooth movement after the application of different force magnitudes in rat molar2009

    • Author(s)
      Gonzales C, Hotokezaka H, Arai Y, Ninomiya T, Tominaga J, Jang I, Hotokezaka Y, Tanaka M, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 79(4) Pages: 703-714

  • [Journal Article] Effects of steroidal and nonsteoridal drugs on tooth movement and root resorption in the rat molar2009

    • Author(s)
      Gonzales C, Hotokezaka H, Matsuo KI, Shibazaki T, Yozgatian J, Darendeliler MA, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 79(4) Pages: 715-726

  • [Journal Article] Effect of celecoxib on emotional stress and pain-related behaviors evoked by experimental tooth movement in the rat2009

    • Author(s)
      Shibazaki T, Yozgatian JH, Zeredo JL, Gonzales C, Hotokezaka H, Koga Y, Yoshida N
    • Journal Title

      Angle Orthod

      Volume: 79(6) Pages: 1169-1174

  • [Presentation] IL-12-and IL-18-mediated nitric oxide induced apoptosis in TNF-α-mediated osteoclastogenesis2011

    • Author(s)
      Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Yoshida N, Takano-Yamamoto T
    • Organizer
      Annual Meeting of the Japanese Orthodontic Society
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20111017-20111120
  • [Presentation] Effects of IFN-γon tooth movement2011

    • Author(s)
      Kohara H, Kitaura H, Yoshimatsu M, Fujimura Y, Morita Y, Eguchi T, Yoshida N
    • Organizer
      Annual Meeting of the Japanese Orthodontic Society
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20111017-20111020
  • [Presentation] Effects of SHIP on TNF-alpha-induced osteoclastogenesis2011

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Yoshida N
    • Organizer
      Annual Meeting of the Japanese Orthodontic Society
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20111017-20111020
  • [Presentation] 矯正学的歯の移動時におけるIL-12の作用について2010

    • Author(s)
      吉松昌子、北浦英樹、藤村裕治、小原悠、森田幸子、江口俊子、吉田教明
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] 矯正学的歯の移動に対するIFN-γの発現およびその影響2010

    • Author(s)
      小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、江口俊子、吉田教明
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] IL-18のTNF-α誘導破骨細胞形成抑制作用におけるT細胞の関与の検討2010

    • Author(s)
      森田幸子、北浦英樹、吉松昌子、藤村裕治、小原悠、江口俊子、吉田教明
    • Organizer
      第69回日本矯正歯科学会大会
    • Place of Presentation
      横浜
    • Year and Date
      20100927-20100929
  • [Presentation] TNF-αによる破骨細胞形成に対してのT細胞のかかわりについての検討2009

    • Author(s)
      北浦英樹、藤村裕治、吉松昌子、小原悠、森田幸子、江口俊子、吉田教明、山本照子
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20091116-20091118
  • [Presentation] L-18による矯正学的歯の移動と歯根吸収の及ぼす影響について2009

    • Author(s)
      森田幸子、北浦英樹、吉松昌子、藤村裕治、小原悠、江口俊子、吉田教明
    • Organizer
      第68回日本矯正歯科学会大会
    • Year and Date
      20091116-20091118
  • [Presentation] IL-12の破骨細胞形成抑制作用におけるT細胞の関与ついて2009

    • Author(s)
      吉松昌子、北浦英樹、藤村裕治、小原悠、森田幸子、江口俊子、吉田教明
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20091116-20091118
  • [Presentation] IFN-γ誘導性のNOによるM-CSF依存性破骨細胞前駆細胞の増殖抑制効果2009

    • Author(s)
      小原悠、北浦英樹、吉松昌子、藤村裕治、森田幸子、江口俊子、吉田教明
    • Organizer
      第68回日本矯正歯科学会大会
    • Place of Presentation
      福岡
    • Year and Date
      20091116-20091118
  • [Presentation] IL-12 inhibits TNF-αmediated osteoclastogenesis via a T cell-independent mechanism in vivo2009

    • Author(s)
      Yoshimatsu M, Kitaura H, Fujimura Y, Kohara H, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, USA
    • Year and Date
      20090911-20090915
  • [Presentation] IL-12-and IL-18-mediated nitric oxide induces apoptosis in TNF-α-induced osteoclastogenesis of bone marrow cells2009

    • Author(s)
      Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Eguchi T, Yoshida N, Takano-Yamamoto T
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, USA
    • Year and Date
      20090911-20090915
  • [Presentation] Effect of bisphosphonates on orthodontic tooth movement in mice2009

    • Author(s)
      Fujimura Y, Kitaura H, Yoshimatsu M, Kohara H, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, USA
    • Year and Date
      20090911-20090915
  • [Presentation] IL-18 inhibits TNF-α-induced osteoclastogenesis in synergy with IL-12 in vivo2009

    • Author(s)
      Morita Y, Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Eguchi T, Takano-Yamamoto T, Yoshida N
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, USA
    • Year and Date
      20090911-20090915
  • [Presentation] IFN-γ-mediated nitric oxide inhibits proliferation of M-CSF-dependent bone marrow macrophages2009

    • Author(s)
      Kohara H, Kitaura H, Fujimura Y, Yoshimatsu M, Morita Y, Eguchi T, Takano-Yamamoto T, Yoshida N
    • Organizer
      Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Denver, USA
    • Year and Date
      20090911-20090915
  • [Presentation] 炎症性サイトカインであるTNF-αによる破骨細胞形成に対するTh1サイトカインの作用について2009

    • Author(s)
      北浦英樹、山本照子
    • Organizer
      第6回東北大学バイオサイエンスシンポジウムおよび第14回学際ライフサイエンスシンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-16
  • [Remarks]

    • URL

      http://ortho.dh.nagasaki-u.ac.jp/

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Published: 2013-07-31  

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