2011 Fiscal Year Final Research Report
The development of effective tooth movement using the specific osteoclast inhibitor and the system of prevention on periodontal disease.
| Project/Area Number |
21592618
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
GOTO Shigemi 愛知学院大学, 歯学部, 教授 (60142577)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAWA Ken 愛知学院大学, 歯学部, 教授 (60301636)
TABUCHI Masako 愛知学院大学, 歯学部, 講師 (30418925)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯学 / 矯正学 / 歯周病予防 / 破骨細胞 / 病理学 |
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| Research Abstract |
We examined the periodontal tissue reaction course of OPG-/-mice using the Waldo method, and we investigated the effect of administering Bisphosphonate(BP) and Reveromycin A(RM-A) on the periodontal tissue. BP and RM-A treatment results in normalization of bone metabolism and loss of alveolar bone during experimental tooth movement in OPG-/-mice. Moreover, the model of the periodontal disease in mouse was established using wire ligature. Further studies are necessary to investigate and development the system of prevention on periodontal disease by control of the bone metabolism.
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