2011 Fiscal Year Final Research Report
Analysis of the influence on the host cells of FDF derived from periodontopathic bacteria and the contribution in the pathogenesis of periodontitis
| Project/Area Number |
21592620
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ARAKAWA Shinichi 東京医科歯科大学, 歯学部附属病院, 助教 (20302888)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯周免疫機能学 / 歯周病原細菌 |
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| Research Abstract |
The FDF was taken in(or invade) a cell and raised oxidation membrane potential after reaching to mitochondria, and it was revealed that the FDF finally aggravated production of IL-8. The gingival crevicular fluid from periodontitis patients and normal subjects(for each 21) was isolated, and measured the anti-FDF antibody titer each. As a result, the antibody titer of periodontitis patients showed significantly higher than that of control group. Furthermore, 3 clinical parameters(Pocket depth, Clinical Attachment Level(CAL) and Bleeding on probing) are correlated with the anti-FDF antibody titer. These results suggest that the titer was associated with the condition of patients.
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[Presentation] 平成21年度患者満足度アンケート調査の分析結果2010
Author(s)
礪波健一,俣木志朗,大林尚人,橋本吉明,荒川真一,鵜澤成一,釼持郁,比嘉りつ子,森薗立男,桜井純蘭,足達淑子,森山啓司,嶋田昌彦
Organizer
第75回口腔病学会学術大会
Place of Presentation
東京
Year and Date
2010-12-04
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