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2011 Fiscal Year Final Research Report

Specification and verification of periodontal pathogens relate to various vascular diseases

Research Project

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Project/Area Number 21592621
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionOsaka Dental University (2011)
Tokyo Medical and Dental University (2009-2010)

Principal Investigator

UMEDA Makoto  大阪歯科大学, 歯学部, 教授 (90193937)

Co-Investigator(Kenkyū-buntansha) INOUE Yoshinori  東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70280964)
Project Period (FY) 2009 – 2011
Keywords血管系疾患 / 歯周病原細菌 / モノクローナル抗体 / 免疫染色 / リンパ節 / バージャー病 / P. gingivalis / T. forsythia
Research Abstract

The monoclonal antibodies effective for the detection of P. gingivalis and T. forsythia localized in tissue specimens were prepared. Periodontal pathogen was detected in diseased gingival tissue and atherosclerosis sample by immunohistochemistry. Oral and vascular samples of Buerger disease patients in Sri Lanka were detected periodontal pathogens by polymerase chain reaction method. The existence of periodontal pathogens in formalin-fixed and paraffin embedded lymph nodes proximal to oral cavity was examined from patients with histories of head and neck cancer. These bacteria invaded in gingival tissues might translocate peripheral arteries via lymph nodes.

  • Research Products

    (11 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (3 results) Book (1 results)

  • [Journal Article] Clinical study of phlebitis migrans and incompetence of the leg's superficial vein in Buerger disease2012

    • Author(s)
      Iwai T, Sato S, Kume H, Inoue Y, Umeda M, Kagayama T, Hirokawa M
    • Journal Title

      Ann Vasc Dis

      Volume: 5巻、No.1 Pages: 45-51

    • DOI

      DOI:10.3400/avd.oa.11.00044

    • Peer Reviewed
  • [Journal Article] The periodontal anaerobe Porphyromonas gingivalis induced platelet activation and increased aggregation in whole blood by rat model2011

    • Author(s)
      Yu KM, Inoue Y, Umeda M, Terasaki H, Chen ZY, Iwai T
    • Journal Title

      Tromb Res

      Volume: 127巻 Pages: 418-425

    • DOI

      DOI:10.1016/j.thromres.2010.12.004

    • Peer Reviewed
  • [Journal Article] Whole-blood platelet aggregation by Porphyromonas gingivalis in patients with peripheral arterial disease2011

    • Author(s)
      Notani H, Inoue Y, Sugano N, Jibiki M, Umeda M, Izumi Y
    • Journal Title

      J Med Dent Sci

      Volume: 58巻 Pages: 7-14

    • URL

      http://www.tmd.ac.jp/english/labs/toshozy

    • Peer Reviewed
  • [Journal Article] Bactericidal effects of a high-power red light-emitting diode on two periodontopathic bacteria in antimicrobial photodynamic therapy in vitro2011

    • Author(s)
      Umeda M, Tsuno A, Okagami Y, Tsuchida F, Izumi Y, Ishikawa I
    • Journal Title

      J Investig Clin Dent

      Volume: 2巻 Pages: 268-274

    • DOI

      DOI:10.1111/J.2041-1626.2011.00071.x

    • Peer Reviewed
  • [Journal Article] バージャー病患者の逍遙性静脈炎、表在静脈弁不全についての考察と新知見2011

    • Author(s)
      岩井武尚、佐藤彰治、久米博子、井上芳徳、梅田誠、加賀山知子、広川雅之
    • Journal Title

      静脈学

      Volume: 22巻、No.1 Pages: 25-31

    • URL

      http://www.js-phlebology.org/journal/index

    • Peer Reviewed
  • [Journal Article] Association between periodontitis and anti-cardiolipin antibodies in Buerger disease2009

    • Author(s)
      Chen YW, Nagasawa T, Wara-Aswapati N, Ushida Y, Wang D, Takeuchi Y, Kobayashi H, Umeda M, Inoue Y, Iwai T, Ishikawa I, Izumi Y
    • Journal Title

      J Clin Periodontol

      Volume: 36巻 Pages: 830-835

    • DOI

      DOI:10.111/J.1600-051X.2009.01467.x

    • Peer Reviewed
  • [Journal Article] Periodontitis and cardiovascular diseases : The link and relevant mechanisms2009

    • Author(s)
      Izumi Y, Nagasawa T, Umeda M, Kobayashi H, Takeuchi Y, Yashiro R, Hormdee D, Suda T, Ushida Y, WaraAswapati N
    • Journal Title

      Japanese Dental Science Review

      Volume: 45巻 Pages: 98-108

    • DOI

      DOI:10.1016/j.jdsr.2009.06.001

    • Peer Reviewed
  • [Presentation] 新規に開発したモノクローナル抗体を用いた歯肉組織中の歯周病原細菌の局在の解明2011

    • Author(s)
      RaJakaruna GA, 梅田誠、内田佳介、古川あすか、和泉雄一、江石義信
    • Organizer
      第59回国際歯科研究学会日本部会(JADR)
    • Place of Presentation
      広島
    • Year and Date
      2011-10-08
  • [Presentation] 新規に開発したモノクローナル抗体を用いた病的歯肉組織中の歯周病原細菌の検出と局在2011

    • Author(s)
      RaJakaruna GA, 内田佳介、梅田誠、古川あすか、和泉雄一、江石義信
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      下関
    • Year and Date
      2011-09-24
  • [Presentation] Detection of periodontal pathogens in gingival tissues using novel MAb2010

    • Author(s)
      Rajakaruna GA, Uchida K, Umeda M, Furukawa A, Suzuki Y, Lokman N, Izumi Y, Eishi Y
    • Organizer
      第58回国際歯科研究学会日本部会(JADR)総会・学術大会
    • Place of Presentation
      北九州市
    • Year and Date
      2010-11-20
  • [Book] ザ・ペリオドントロジー2009

    • Author(s)
      梅田誠、和泉雄一
    • Total Pages
      86-88, 265-267
    • Publisher
      永末書店

URL: 

Published: 2013-07-31  

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