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2011 Fiscal Year Final Research Report

Pathological roles of tissue inhibitors of metalloproteinases in the tissues of drug-induced fibrous gingival over growth.

Research Project

  • PDF
Project/Area Number 21592622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionNiigata University

Principal Investigator

KUBOTA Takehiko  新潟大学, 医歯学総合病院, 講師 (50303136)

Co-Investigator(Kenkyū-buntansha) NAKASONE Naohiro  新潟大学, 医歯学総合病院, 医員 (20447634)
Co-Investigator(Renkei-kenkyūsha) MARUYAMA Satoshi  新潟大学, 医歯学総合病院, 講師 (30397161)
NOUNO Kaname  新潟大学, 医歯学系, 助教 (80422608)
Project Period (FY) 2009 – 2011
Keywords歯周免疫機能学
Research Abstract

We have reported the 1^<st> report "Gene expression and immunohistochemical protein localization of TIMP-3 and TIMP-in gingival overgrowth and periodontitis-affected gingival tissues" Archs Oral Biology(2009). Then I have received the Academic Senior Investigator's Award for this series of studies in 2009 from Japanese Society of Conservative Dentistry(Review 2010)。The 2^<nd> and 3^<rd> reports :"Microarray and data-mining analyses for specific gene expression in drug-induced gingival overgrowth tissues. Archs Oral Biology(2011)", and "Altered gene expression pattern and specific biological pathways in periodontitis-affected gingival tissues." J Periodont Res(2011) have published in international scientific peer review journals.

  • Research Products

    (11 results)

All 2011 2010 2009 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues2011

    • Author(s)
      Abe D, Kubota T, Morozumi T, Shimizu T, Nakasone N, Itagaki M, Yoshie H.
    • Journal Title

      J Periodont Res

      Volume: 46 Pages: 345-353

    • Peer Reviewed
  • [Journal Article] Microarray and quantitative RT-PCR analyses in calcium-channel blockers induced gingival overgrowth tissues of periodontitis patients2011

    • Author(s)
      Shimizu T, Kubota T, Nakasone N, Abe D, Morozumi T, Yoshie H
    • Journal Title

      Arch Oral Biol

      Volume: 56 Pages: 277-284

    • Peer Reviewed
  • [Journal Article] 歯周炎組織破壊における生体酵素動態と歯周炎感受性診断2010

    • Author(s)
      久保田健彦、ミニレビュー
    • Journal Title

      日本歯科保存学会雑誌

      Volume: 53巻 Pages: 6-8

    • Peer Reviewed
  • [Journal Article] Differential gene and protein expression of tissue inhibitors of metalloproteinases(TIMP)-3 and TIMP-4 in gingival tissues from drug induced gingival overgrowth2009

    • Author(s)
      Nakasone N, Kubota T, Hoshino C, Nohno K, Itagaki M, Shimizu T, Yoshie H
    • Journal Title

      Arch Oral Biol

      Volume: 54 Pages: 634-641

    • Peer Reviewed
  • [Presentation] Alzheimer's disease pathway was accelerated in periodontitis-affected gingival tissues2010

    • Author(s)
      Kubota T, Abe D, Shimizu T, Nakasone N, Morozumi T, Yoshie H
    • Organizer
      IADR 88th General Session 2010
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      20100714-17
  • [Presentation] ACE及びTIMP-3の薬物性歯肉増殖症と歯周炎の歯肉組織における遺伝子発現とタンパク質局在2010

    • Author(s)
      冨田尊志、久保田健彦、中曽根直弘、飯山真奈美、両角俊哉、永田昌毅、堀水慎、濃野要、吉江弘正
    • Organizer
      第54回秋季日本歯周病学会学術大会
    • Place of Presentation
      下関市
    • Year and Date
      2010-09-24
  • [Presentation] アルツハイマー病関連遺伝子は歯周炎罹患歯肉において転写発現亢進している2010

    • Author(s)
      久保田健彦、阿部大輔、清水太郎、中曽根直弘、両角俊哉、吉江弘正
    • Organizer
      第53回秋季日本歯周病学会学術大会
    • Place of Presentation
      高松市
    • Year and Date
      2010-09-19
  • [Presentation] Transcriptomes in sites with drug-induced gingival-overgrowth Microarray and qRT-PCR analyses2009

    • Author(s)
      Shimizu T, Kubota T, Abe D, Morozumi T, Nakasone N, Yoshie H
    • Organizer
      EUROPERIO6
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      20090604-06
  • [Presentation] 薬剤性歯肉増殖症の感受性と特異的遺伝子発現の網羅的解析2009

    • Author(s)
      清水太郎、久保田健彦、阿部大輔、両角俊哉、中曽根直弘、吉江弘正
    • Organizer
      第52回春季日本歯周病学会学術大会
    • Place of Presentation
      岡山市
    • Year and Date
      20090515-16
  • [Book] 歯周組織再生と歯根膜.歯界展望別冊「歯と歯列を守るための歯根膜活用術」2011

    • Author(s)
      久保田健彦、吉江弘正
    • Total Pages
      58-61
    • Publisher
      医歯薬
  • [Remarks] (1)日本歯科保存学会学術賞受賞論文のURL

    • URL

      http://wwwsoc.nii.ac.jp/jscd/member/pdf/vol53_no1/6.pdf

URL: 

Published: 2013-07-31  

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