2011 Fiscal Year Final Research Report
Cross reactivity of archaeal chaperonin with human CCT involved in the pathogenesis of periodontitis and autoimmune disease
| Project/Area Number |
21592624
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MAEDA Hiroshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (00274001)
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| Co-Investigator(Kenkyū-buntansha) |
TAKASHIBA Shogo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
KOKEGUCHI Susumu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (10144776)
TANIMOTO Ichiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00280686)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 歯周病 / 古細菌 / シャペロニン / 自己免疫応答 / 自己免疫疾患 |
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| Research Abstract |
Periodontitis is known to be an infectious disease caused by oral bacteria. Besides bacteria, it has recently been reported that methanogenic Archaea is also involved in the pathogenesis of periodontitis. Archaea possess group II chaperonin that is homologous to human chaperonin CCT. Due to the sequence similarity, archaeal chaperonin has the potential to be a cross-reactive antigen of human CCT. We examined the reactivity of sera from patients with periodontitis or autoimmune diseases to the chaperonins. Antibody to the archaeal chaperonin and human CCT was detected in some patients. The results demonstrated the possible induction of autoimmune reaction targeting the group II chaperonin. Cross reaction between the archaeal and human chaperonin may be a trigger for autoimmune reaction.
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