2011 Fiscal Year Final Research Report
Analysis an accelerative mechanism of atherosclerosis by periodontitis-effect of inflammatory alveolar bone resorption-
| Project/Area Number |
21592627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
UKAI Takashi 長崎大学, 大学病院, 講師 (20295091)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Yoshitaka 長崎大学, 大学院・医歯薬学総合研究科, 教授 (60159100)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 骨吸収 / 歯周病 / アテローム性動脈硬化 / 破骨細胞 / RANKL / 泡沫化細胞 |
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| Research Abstract |
We studied an effect of inflammatory bone loss in atherosclerosis to clarify the mechanism of relationship between periodontal diseases and atherosclerosis. As the results, we revealed atherosclerosis accelerated when mice were induced inflammatory bone loss. In the tissues of atherosclerosis, RANKL positive cells were observed by immunohistochemistry. Furthermore, foam cell formation was accelerated by RANKL stimulation in vitro.
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