2011 Fiscal Year Final Research Report
Establishment of Peri-implantitis treatment using a dual-purpose graft and cell transplantation.
| Project/Area Number |
21592629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
MATSUYAMA Takashi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (40253900)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Takehiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (60419653)
MIYAMOTO Motoharu 鹿児島大学, 大学院・医歯学総合研究科, 助教 (50452941)
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| Project Period (FY) |
2009 – 2011
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| Keywords | インプラント周囲炎 / 脱感染処理 / 細胞増殖因子 / マイクロカプセル / 骨再生 |
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| Research Abstract |
The purpose of the present study was to evaluate cell biocompatibility and decontamination effect using β-TCP air-abrasion and BMP-2-incorporated PLGA microcapsule. β-TCP air abrasion decontamination led to microscopically visible alterations of the implant surface, however, it seems have a good potential to remove cytotoxic bacterial components from titanium surfaces. BMP-2 encapsulation efficiency from PLGA microcapsules was 37.5%. BMP-2 incorporated PLGA microcapsule elevated alkaline phosphatase activity in preosteoblasts. These results obtained suggest that encapsulated BMP-2 induces bone regeneration on titanium surface after removing cytotoxic bacterial components by β-TCP air-abrasion.
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[Journal Article] Ikuro Maruyama Involvement of the endocannabinoid system in periodontal healing2010
Author(s)
Sayaka Kozono, Takashi Matsuyama, Kamal Krishna Biwasa, Ko-ichi Kawahara, Yumiko Nakajima, Takehiko Yoshimoto, Yutaka Yonamine, Hideshi Kadomatsu, Salunya Tancharoen, Teruto Hashiguchi, Kazuyuki Noguchi
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Journal Title
Biochem Biophys Res Commun
Volume: 394(4)
Pages: 928-933
DOI
Peer Reviewed
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