2011 Fiscal Year Final Research Report
Study on the prevention and regulation of periodontal diseases by using anti-oxidants
| Project/Area Number |
21592632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Ohu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SATOH Kazue 昭和大学, 医学部, 教授 (90053941)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ボスウェリン酸 / 抗酸化作用 / 抗炎症作用 |
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| Research Abstract |
Recurrent bacteial infection from periodontal pockets affects chronic inflammatory reactions at periodontium and then the periodontal tissues tend to be destroyed. Many inflammatory mediators and reactive oxygen species(ROS) are aberrantly produced in periodontium. Therefore, anti-inflammatory and anti-oxidative products are used in order to analyze if they can inhibit the progression of periodontitis. In this study, we have investigated if oral administration of boswellic acid inhibit the production of ROS and anti-stress proteins. Boswellic acid tended to inhibit the ROS in the saliva of subjects, although its difference was not significant. The concentration of cortisol in the saliva was significantly reduced by boswellic acid administration. These results suggest the possibility that boswellic acid can manipulate the overproduction of ROS in the oral cavity.
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