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2011 Fiscal Year Final Research Report

Comprehensive gene analysis in junctional epithelium

Research Project

  • PDF
Project/Area Number 21592634
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionShowa University

Principal Investigator

YAMAMOTO Matsuo  昭和大学, 歯学部, 教授 (50332896)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Gou  昭和大学, 歯学部, 助教 (80384189)
USUI Michihiko  昭和大学, 歯学部, 助教 (10453630)
Project Period (FY) 2009 – 2011
Keywords付着上皮 / 遺伝子発現 / 自然免疫 / 自然炎症 / 歯周病
Research Abstract

Junctional epithelium(JE) is important for the maintenance of periodontal tissues without keratosis, and indicates specific characteristics. Our comprehensive gene expression analysis in JE demonstrated that several molecules concerning innate immunity or homeostatic inflammation such as S100A9, S100A8, CXCL1, CXCL2 and SLPI, has been confirmed. Those result showed that JE has different gene expression pattern from keratinized oral epithelium.

  • Research Products

    (14 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (6 results)

  • [Journal Article] The role of junctinal epithelium periodontal innate defense and homeostasis2012

    • Author(s)
      Tsukamoto Y, Usui M, Yamammoto G, Takagi Y, Tachikawa T, Yamamoto M, Nakamura M
    • Journal Title

      J Periodontal Res

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] MAPKs, activator protein-1 and nuclear factor-κB mediate production of interleukin-1β-stimulated cytokines, prostaglandin E(2) and MMP-1 in human MAPperiodontal ligament cells2011

    • Author(s)
      Murayama R, Kobayashi M, Takeshita A, Yasui T, Yamamoto M
    • Journal Title

      J Periodontal Res

      Volume: vol.46, No.5 Pages: 568-575

    • Peer Reviewed
  • [Journal Article] 超音波照射のヒト歯肉上皮細胞に対する影響について2011

    • Author(s)
      臼井通彦, 滝口尚, 史春, Guruudivaa E, 宮澤康, 菅野真莉加, 野瀬冬樹, 斎藤彰大, 菊池真理子, 冨永和宏, 西原達次, 根岸洋一, 山本松男、
    • Journal Title

      日歯保存誌

      Volume: 54巻6号 Pages: 424-431

    • Peer Reviewed
  • [Journal Article] Comprehensive analysis of gene expression in the junctional epithelium by laser microdissection and microarray analysis2010

    • Author(s)
      Hayashi Y, Matsunaga T, Yamamoto G, Nishii K, Usui M, Yamamoto M, Tachikawa T
    • Journal Title

      J Periodont Res

      Volume: Vol.45, No.5 Pages: 618-625

    • Peer Reviewed
  • [Journal Article] Oxidized low-density lipoproteins increases IL-8 production in human gingival epithelial cell line Ca9-222010

    • Author(s)
      Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M
    • Journal Title

      J Periodont Res

      Volume: Vol.45, No.4 Pages: 488-495

    • Peer Reviewed
  • [Journal Article] 歯周病が全身に及ぼす影響2010

    • Author(s)
      臼井通彦, 山本松男
    • Journal Title

      月刊糖尿病

      Volume: 2巻, 13号 Pages: 15-20

  • [Journal Article] 歯周病と全身疾患リスクは2010

    • Author(s)
      臼井通彦, 山本松男
    • Journal Title

      肥満と糖尿病

      Volume: 9巻, 5号 Pages: 752-753

  • [Journal Article] Docosahexaenoic acid induces adipose differentiation-related protein through activation of retinoid X receptor in human choriocarcinoma BeWo cells2009

    • Author(s)
      Suzuki K, Yamamoto M, Itabe H, 他
    • Journal Title

      Biol. Pharm. Bull

      Volume: Vol.32 Pages: 1177-82

    • Peer Reviewed
  • [Presentation] Oxidized LDL enhances IL-8 production in gingival epithelial cell2010

    • Author(s)
      Suzuki K, Sakiyama Y, Nagahama Y, Usui M, Yamamoto M.
    • Organizer
      The 96th Annual Meeting of American Academy of Periodontology in collaboration with the Japanese Society of Periodontology
    • Place of Presentation
      Honolulu
    • Year and Date
      2010-11-01
  • [Presentation] 超音波照射の歯肉上皮細胞に対する影響について2010

    • Author(s)
      山本松男, 史春, 臼井通彦, 滝口尚, 菅野真莉加, 野瀬冬樹, 根岸洋一, 富永和宏, 西原達次
    • Organizer
      日本歯科保存学会2010年度秋季学術大会(第133回)
    • Place of Presentation
      岐阜
    • Year and Date
      2010-10-28
  • [Presentation] Naringeninは黄色ブドウ球菌のTLR2を介した炎症応答を抑制する2010

    • Author(s)
      島田絵里, 片岡嗣雄, 福羅勝久, 柴田健一郎, 山本松男, 五十嵐武
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-27
  • [Presentation] Streptococcus mutansの貪食抵抗性におけるリポ蛋白質PPiAの役割2010

    • Author(s)
      向原正, 有本隆文, 谷口誠, 高橋真和, 山本松男, 五十嵐武
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-03-27
  • [Presentation] リゾリン脂質・LPA(lysophosphatidic acid)の破骨細胞前駆細胞株Raw264.7に対する影響2009

    • Author(s)
      臼井通彦, 宮園あがさ, 山本松男
    • Organizer
      第46回日本口腔組織培養学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2009-12-05
  • [Presentation] エナメル芽細胞におけるCaspase-14の役割2009

    • Author(s)
      宮園あがさ, 須澤徹夫, 山本松男, 上條竜太郎
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Place of Presentation
      新潟
    • Year and Date
      2009-09-11

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Published: 2013-07-31  

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