2011 Fiscal Year Final Research Report
Molecular biological study on the mechanism of alveolar bone metabolism through the toll-like receptor 5
| Project/Area Number |
21592639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DEYAMA Yoshiaki 北海道大学, 大学院・歯学研究科, 准教授 (80271667)
KANEHIRA Takashi 北海道大学, 北海道大学病院, 講師 (90194935)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 予防歯科学 / 歯槽骨 / Toll様受容体5 / フラジェリン / MCP-1 / OPG |
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| Research Abstract |
Flagellin, the ligand of Toll like receptor 5, markedly increased the expression of MCP-1 which is one of the CC chemokine, in a dose-dependent manner on osteoblastic MC3T3-E1 cells. In addition, flagellin was significantly suppressed the OPG mRNA expression. Furthermore, anti-MCP-1 antibody was further down-regulated the flagellin-suppressed OPG mRNA expression. These results indicate that osteoblasts are involved in host defense as well as bone metabolism.
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