2011 Fiscal Year Final Research Report
Mechanisms of drug efflux by two-component control system in oral Streptococci
| Project/Area Number |
21592653
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
SHIOTA Susumu 九州大学, 歯学研究院, 助教 (00150467)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMASHITA Yoshihisa (20192403)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細菌 / シグナル伝達 / 発現制御 |
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| Research Abstract |
Streptococcus mutans, a major etiological agent of dental caries, is resistant to bacitracin. We studied the mechanisms of two-component signal transduction system(TCS) that controlled the expression of the bacitracin resistant operon. As a result, under the bacitracin stimulation the response regulator of TCS specifically bind to a putative promoter region of ABC transpoter genes, then accelerate the expression of these genes. The mutant that substituted asparagine for aspartic acid at position 54 could not bind to a putative promoter and also shows the susceptibility to bacitracin.
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