2011 Fiscal Year Final Research Report
Pathogenesis of obstructive sleep apnea syndrome for the primary factor inducing metabolic syndrome
| Project/Area Number |
21592654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
OI Kumiko 長崎大学, 大学院・医歯薬学総合研究科, 教授 (80134732)
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| Co-Investigator(Kenkyū-buntansha) |
AYUSE Takao 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20222705)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 閉塞型睡眠時無呼吸症候群 / 上気道 / メタボリックシンドローム |
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| Research Abstract |
We have tried to establish the two different mouse upper airway experimental model to explore the pathophysiological factor to induce obstructive sleep apnea syndrome. We have tested the neuromuscular compensatory response under general anesthesia by analysis of passive and active upper airway collapsibility (Pcrit and resistance calculated pressure flow relationship). However, with spontaneous breathing under general anesthesia, the influence of muscle relaxant by anesthetic agent may cause major effect on upper airway. We have also established the rabbit model to test upper airway collapsibility with spontaneous breathing under general anesthesia. We have found moderate increase of body weight did not cause significant change in Pcrit of rabbit upper airway. We have also found that instillation of surfactant into pharyngeal region slightly decrease Pcrit as reported in previous study. In conclusion, we could not exclude the effect of general anesthesia on both mouse and rabbit experiment to evaluate upper airway functions.
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