2011 Fiscal Year Final Research Report
Effect of GABA on excitatory conduction in nociceptive sensory neurons
| Project/Area Number |
21600014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kyorin University |
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Principal Investigator |
YAGI Junichi 杏林大学, 医学部, 講師 (90265760)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 神経科学 / 痛覚 / 感覚神経 / シナプス前抑制 / パッチクランプ記録 |
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| Research Abstract |
Signal transmission from sensory neurons to the secondary neurons in the spinal cord is modulated by presynaptic inhibition, in whichg-aminobutyric acid(GABA) reduces release of neurotransmitters in the presynaptic sensory neuronal terminals. A novel method was developed toinvestigate the underlying mechanisms. It was suggested that the presynaptic inhibition would be due to GABA-induced membrane depolarization, leading to a blockade of action potential propagation.
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