2011 Fiscal Year Final Research Report
Epigenetic regulation of embryonic and somatic stem cells by Polycomb
| Project/Area Number |
21602006
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Stem cell biology and medical science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ENDOH Mitsuhiro 独立行政法人理化学研究所, 免疫器官形成研究グループ, 研究員 (40391883)
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| Co-Investigator(Renkei-kenkyūsha) |
KOSEKI Haruhiko 独立行政法人理化学研究所, 免疫器官形成研究グループ, グループリーダー (40225446)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ES細胞 / 幹細胞 / エピジェネティクス / クロマチン / 転写 / 発生 / 分化 |
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| Research Abstract |
Analysis using Ring1A/B conditional knockout embryonic stem(ES) cells revealed that Ring1A/B contribute to maintain ES cell identity by repressing developmental regulators. We also reported that Ring1A/B-mediated mono-ubiquitination of histone H2A is an essential step for transcriptional repression of the target genes. Furthermore, we found that histone ubiquitination activity of Ring1A/B is also required for the maintenance of epiblast stem cells derived from a 6.5 dpc embryo.
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[Journal Article] Bernstein BE and Koseki H Histone H2A mono-ubiquitination is a crucial step to mediate PRC1 dependent repression of developmental genes to maintain ES cell identity2012
Author(s)
Endoh M, Endo TA, Endoh T, Isono K, Sharif J, Ohara O, Toyoda T, Ito T, Eskeland R, Bickmore WA, Vidal M
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Journal Title
PLoS Genet
Volume: (in press)
Peer Reviewed
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[Journal Article] The Hbo1-Brd1/Brpf2 complex is responsible for global acetylation of H3K14 and required for fetal liver erythropoiesis2011
Author(s)
Mishima Y, Miyagi S, Saraya A, Negishi M, Endoh M, Endo TA, Toyoda T, Shinga J, Katsumoto T, Chiba T, Yamaguchi N, Kitabayashi I, Koseki H, Iwama A
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Journal Title
Blood
Volume: 118
Pages: 2443-2453
Peer Reviewed
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[Journal Article] Mammalian polycomb-like Pcl2/Mtf2 is a novel regulatory component of PRC2 that can differentially modulate polycomb activity both at the Hox gene cluster and at Cdkn2a genes2011
Author(s)
Li X, Isono K, Yamada D, Endo TA, Endoh M, Shinga J, Mizutani-Koseki Y, Otte AP, Casanova M, Kitamura H, Kamijo T, Sharif J, Ohara O, Toyada T, Bernstein BE, Brockdorff N, Koseki H
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Journal Title
Mol Cell Biol
Volume: 31
Pages: 351-364
Peer Reviewed
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