2012 Fiscal Year Final Research Report
Effects of visceral sensitivity on brain processing of stress stimuli in childhood
| Project/Area Number |
21610003
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | Tohoku University |
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Principal Investigator |
WATANABE Satoshi 東北大学, 大学院・医学系研究科, 非常勤講師 (40431506)
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| Co-Investigator(Kenkyū-buntansha) |
KANAZAWA Motoyori 東北大学, 大学院・医学系研究科, 講師 (70323003)
FUKUDO Shin 東北大学, 大学院・医学系研究科, 教授 (80199249)
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| Project Period (FY) |
2009 – 2012
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| Keywords | 内臓知覚過敏 / 過敏性腸症候群 / 小児腹痛 / 養育態度 / 注意制御 / 事象関連電位 / 聴覚誘発電位 / ストレス感受性 |
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| Research Abstract |
In the present study, we investigated the brain processing of stress stimuli with functional abdominal pain features of children. Children aged seven and their mothers (200 pairs) participated. Brainstem auditory evoked potential (BAEP) were triggered by 75 dB click sounds. Event-related pontential (ERP) were recorded while children performed a modified Go/Nogo task. The N2 peak of ERP in the abdominal pain group had significantly shorter peak latency than control. The present ERP findings suggest the possibility that relevant viscerosensory information is rapidly conveyed to the stress-related brain network and is processed by the biased attention of children with functional abdominal pain.
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[Journal Article] Enhanced auditorybrainstem response and parental bonding style in children with gastrointestinal symptoms2012
Author(s)
Seino S, Watanabe S, Ito N, Sasaki K, Shoji K, Miura S, Kozawa K, Nakai K, Sato H, Kanazawa M, Fukudo S
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Journal Title
PLoS One
Volume: 7(3)
Pages: e32913
DOI
Peer Reviewed
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[Journal Article] Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling2012
Author(s)
Aizawa E, Sato Y, Kochiyama T, Saito N, Izumiyama M, Morishita J, Kanazawa M, Shima K, Mushiake H, Hongo M, Fukudo S
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Journal Title
Gastroenterology
Volume: 143(5)
Pages: 1188-1198
DOI
Peer Reviewed
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