A research for developmental disorders using the eye-movement measure and the brain functional near-infrared spectroscopy

2011 Fiscal Year Final Research Report

• Project/Area Number: 21610011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Children studies (Studies of environment on children)
• Research Institution: Osaka University
• Principal Investigator: KITAMURA Yuri 大阪大学, 医学系・研究科, 准教授 (90294074)
• Co-Investigator(Renkei-kenkyūsha): KOBAYASHI Yasushi 大阪大学, 生命機能研究科, 准教授 (60311198) ; TANIIKE Masako 大阪大学, 連合小児発達学研究科, 教授 (30263289)
• Project Period (FY): 2009 – 2011
• Keywords: 広汎性発達障害 / 眼球運動計測 / サッカード / 注意欠陥多動性障害 / バイオマーカー

Research Abstract

In this study, we adopted a very simple behavioral paradigm in which subjects are asked to maintain their eyes on the central fixation point and to simply follow peripheral visual stimuli by rapid eye movements(saccades). It has been shown previously that ADHD have problems with visual fixation and visually guided saccades. Here, we examined whether interactions between fixation and saccades are regulated appropriately in ADHD. We took advantage of gap effect, in which saccade initiation is facilitated by disappearance of the central fixation point before appearance of a peripheral target. Consistent with the previous studies, we confirmed that (1) reaction times were longer in ADHD than typically developing children(TD), and (2) reaction times were decreased with ages in both ADHD and TD. Furthermore, we found that gap effects were attenuated in ADHD regardless of ages. Besides, there was no correlation between gap effects and ADHD-RS or CBCL, suggesting that gap effects might capture deficits that cannot be identified by qualitative behavioral evaluation. This attenuation of the gap effect could become an objective measurement to support diagnosis and treatment of ADHD quantitatively.

Research Products

• [Journal Article] フラクタル次元を用いた小児頭部MR画像からの皮質形成異常推定法 (2011)
  • Author(s): 川上順祥、小橋昌司、倉本圭、喜多村祐里、下野久理子、石川智基、谷池雅子、畑豊
  • Journal Title: The Institute of Electronics, Information and Communication Engineers technical report Volume: 110巻 Pages: 109-114
  • Peer Reviewed
• [Journal Article] Sacccadic eye movements as a neural correlate measure of preparatory set in children with ADHD (2010)
  • Author(s): Kitamura-Y, Matsuo-Y, Taniike-M, Mohri-I, Kobayashi-Y
  • Journal Title: Neuroscience Research Volume: 68巻 Pages: e96
  • Peer Reviewed
• [Journal Article] Free placement trans-skull doppler system with 1. 0 MHz array ultrasonic probe (2010)
  • Author(s): Nakamura-M, Kitamura-Y, Yanagida-T, Kobashi-S, Kuramoto-K and Hata-Y
  • Journal Title: Proceedings of the 2010 IEEE International conference on Systems, Man and Cybernetics Volume: 1巻 Pages: 1370-1374
  • Peer Reviewed
• [Journal Article] Statistical Quantification of brain shape deformation with homologous brain shape modeling (2010)
  • Author(s): Yamaguchi-K, Kobashi-S, Kuramoto-K, Kitamura-Y, Mohri-I Imawaki-S, Taniike-M and Hata-Y
  • Journal Title: Proceedings of the 2010 World Automation Congress Volume: 1巻
  • Peer Reviewed
• [Journal Article] Data synthesis for trans-skull brain imaging by 0. 5 and 1. 0MHzultrasonic array systems (2010)
  • Author(s): Yagi-N, Oshiro-Y, Ishikawa-O, Hiramatsu-G, Hata-Y, Kitamura-Y and Yanagida-T
  • Journal Title: Proceedings of the 2010 IEEE International conference on Systems, Man and Cybernetics Volume: 1巻 Pages: 1524-1529
  • Peer Reviewed
• [Journal Article] Estimation method of cortical dysplasia degree using neural network in pediatric brain MRImages (2010)
  • Author(s): Kawakami-N, Kobashi-S, Kuramoto-K, Kitamura-Y, Shimono-K, Imawaki-S, Taniike-M and Hata-Y
  • Journal Title: International Symposium on advanced intelligent system(SCIS & ISIS 2010) Volume: 1巻 Pages: 1399-1402
  • Peer Reviewed
• [Journal Article] Association study of the G72 gene with schizophrenia in a Japanese population : a multicenter study (2009)
  • Author(s): Kazutaka Ohi, Yuri Kitamura(36人中の14番目) Masasothi Takeda, et al.
  • Journal Title: Schizophrenia Research Volume: 109巻 Pages: 80-85
  • Peer Reviewed
• [Journal Article] 眼球運動計測および光脳機能イメージング技術を用いた自閉症の早期診断法と治療訓練法の開発 (2009)
  • Author(s): 喜多村祐里
  • Journal Title: 公益法人加藤記念難病研究助成基金平成20年度助成報告 Volume: 22巻 Pages: 11-16
• [Presentation] サッケード眼球運動計測を用いた小児ADHD患者の脳内基盤に関する検討 (2010)
  • Author(s): 喜多村祐里
  • Organizer: 第33回日本神経科学会大会
  • Place of Presentation: 神戸コンベンションセンター
  • Year and Date: 2010-09-03
• [Book] ストレス百科事典「記憶とストレス」,「月経周期とストレス」,「小児期ストレス」,「小児の身体的虐待」,「脳代謝イメージング」,「脳と脳領域」 (2009)
  • Author(s): 喜多村祐里(分担執筆)
  • Total Pages: 481-486, 750-754, 1257-1261, 1271-1273, 2179-2184, 2185-2190
  • Publisher: 丸善
• [Book] ブロナンセリン100の報告「ブロナンセリンへの置換により反響言語の減少と服薬アドヒアランスの向上が得られ、社会復帰を遂げた一例」 (2009)
  • Author(s): 喜多村祐里(分担執筆)
  • Total Pages: 243-245
  • Publisher: 星和書店