2011 Fiscal Year Final Research Report
Effect of offspring on dam behavior
| Project/Area Number |
21610019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Children studies (Studies of environment on children)
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
TADANO Takeshi 東北薬科大学, 薬学部, 名誉教授 (80104082)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWASAI Osamu 東北薬科大学, 薬学部, 講師 (50296018)
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Yuichiro 東京有明医療大学 (50057361)
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| Project Period (FY) |
2009 – 2011
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| Keywords | うつ病 / 育児放棄 / 母性行動 / ドパミン |
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| Research Abstract |
Olfactory bulbectomy(OBX) animals are considered a putative model of depression. In this study, we investigated the change of maternal behavior in OBX mice. The number of OBX mother's pups significantly decreased per day. The causes were suggested that OBX disrupted both the onset of maternal behavior and reward function. Furthermore, the behavioral data demonstrated that the disruption of maternal behavior in OBX mothers is related to depressed dopaminergic function in the central nervous system induced by OBX. However, our findings concerning dopaminergic function suggest that the disruptions in OBX mice are not simply due to changes in tyrosine hydroxylase levels or dopamine receptor number in the nucleus accumbens.
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