2011 Fiscal Year Final Research Report
Single molecule analyses around the synaptic membrane formed on glass
| Project/Area Number |
21650073
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
HIRANO Tomoo 京都大学, 大学院・理学研究科, 教授 (50181178)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | シナプス / グルタミン酸受容体 / 全反射顕微鏡 / 長期増強 / 細胞培養 |
|---|
| Research Abstract |
Information transmission between neurons takes place at synapses. Here, we have succeeded to form postsynaptic membrane directly on the glass and to observe the movement of receptor molecules with high spatial and temporal resolution using total internal reflection fluorescent microscopy. We have demonstrated that different subtypes of glutamate receptor accumulate at the postsynaptic membrane through distinct routes during long-term potentiation, which is the neuronal activity dependent enhancement of synaptic transmission and has been regarded as a basis of learning and memory.
|
Research Products
(13 results)
-
-
-
[Journal Article] Control of cortical axon elongation by a GABA-driven Ca2+ calmodulin-dependent protein kinase cascade2009
Author(s)
Ageta-Ishihara N, Takemoto-Kimura S, Nonaka M, Adachi-Morishima A, Suzuki K, Kamijo S, Fujii H, Mano T, Blaeser F, Chatila T, Mizuno H, Hirano T, Tagawa Y, Okuno H & Bito H
-
Journal Title
J. Neurosci
Volume: 29
Pages: 13720-13729
Peer Reviewed
-
-
-
[Journal Article] Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells
Author(s)
Muguruma K, Nishiyama A, Ono, Y, Miyawaki H, Mizuhara E, Hori S, Kakizuka A, Obata K, Yanagawa Y, Hirano T & Sasai, Y
-
Journal Title
Nature Neurosci
Volume: 13
Pages: 1171-1180
DOI
Peer Reviewed
-
-
-
-
-
-
-
