2011 Fiscal Year Final Research Report
Analysis of physiological role of daily rhythms of adult neurogenesis
| Project/Area Number |
21650075
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SANADA Yoshikado 東京大学, 大学院・理学系研究科, 准教授 (50431896)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 成体ニューロン新生 / 海馬 / 概日時計 |
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| Research Abstract |
Adult neurogenesis takes place in specific regions of the mammalian brain such as the subventricular zone in the forebrain and the dentate gyrus in the hippocampus. I found that neuron production in the dentate gyrus shows a day/night variation throughout the day. The daily variation is controlled by the circadian clock. Importantly, suppression of the neuron production causes altered mood of mice, implicating the time-of-day-dependent regulation of neuron production is important for mood stabilization.
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