The possibility of the gut flora as a new health index-validation from the association between exercise, lifestyle and the gut flora

2011 Fiscal Year Final Research Report

• Project/Area Number: 21650178
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Applied health science
• Research Institution: Hirosaki University
• Principal Investigator: UMEDA Takashi 弘前大学, 大学院・医学研究科, 准教授 (50311535)
• Co-Investigator(Kenkyū-buntansha): NAKAJI Shigeyuki 弘前大学, 大学院・医学研究科, 教授 (10192220) ; TAKAHASHI Ippei 弘前大学, 大学院・医学研究科, 講師 (70400132) ; MATSUZAKA Masashi 弘前大学, 大学院・医学研究科, 助教 (70431434)
• Project Period (FY): 2009 – 2011
• Keywords: 住民健診 / 健康指標 / 応用健康科学 / 生活習慣病 / 腸内細菌

Research Abstract

The simple measuring method of the gut flora using the molecular biological technique was developed recently. We examined the characteristic of the expression patterns of the gut flora using this method in general populations.
We verified whether observing the expression patterns of the gut flora would be effective as new health indicator and a screening index of a lifestyle-related disease. We examined all survey contents in this study with the result of the health-check up in the Iwaki Health Promotion Project.
The expression ratio of OTU332 (lactic acid bacterium) in the lean person group was significantly higher than those in the obesity group and the standard group in this result. This result suggested that obesity was significantly related to the expression patterns of gut flora, and it was one of the lifestyle-related diseases and the main risk factor of the lifestyle-related disease. This result suggested that a lactic acid bacterium might become the obese protective factors.
In addition, we are considered and analyzing in details now about the associations between lifestyle related diseases expect for obesity and the expression pattern of gut flora.

Research Products

• [Journal Article] Effect of human gut microbiota on methane production (2011)
  • Author(s): Hasebe T, Umeda T, Danjo K, Takahashi I, Matsuzaka M, Kudo J, Semato M, Saito Y, Hisada T, Benno Y, Nakaji S, Hakamada K
  • Journal Title: Hirosaki Med J Volume: 62(1) Pages: 7-17
• [Journal Article] Medical problems and risk factors of metabolic syndrome among radiographic knee osteoarthritis patients in the Japanese general population (2011)
  • Author(s): Inoue R, Ishibashi Y, Tsuda E, Yamamoto Y, Matsuzaka M, Takahashi I, Danjo K, Umeda T, Nakaji S, Toh S
  • Journal Title: J Orthop Sci Volume: 16(6) Pages: 704-9
• [Journal Article] The relationship between serum selenium concentration and neutrophil function in peripheral blood (2011)
  • Author(s): Lee S, Takahashi I, Matsuzaka M, Yamai K, Danjo K, Kumagai T, Umeda T, Itai K, Nakaji S
  • Journal Title: Biol Trace Elem Res Volume: 144(1-3) Pages: 396-406
• [Journal Article] Effect of alcohol drinking and cigarette smoking on neutrophil functions in adults (2011)
  • Author(s): Sato J, Takahashi I, Umeda T, Matsuzaka M, Danjyo K, Tsuya R, Kida K, Takami H, Nakaji S
  • Journal Title: Luminescence Volume: 26(6) Pages: 557-64
• [Journal Article] Assessment of the Center for Epidemiological Studies Depression Scale factor structure among middle-aged workers in Japan (2011)
  • Author(s): Sugawara N, Yasui-Furukori N, Sasaki G, Umeda T, Takahashi I, Danjo K, Matsuzaka M, Kaneko S, Nakaji S
  • Journal Title: Psychiatry Clin Neurosci Volume: 55(1) Pages: 109-11
• [Journal Article] 一般住民の腸管内メタン産生と腸内細菌に関する研究 (2010)
  • Author(s): 長谷部達也, 梅田孝, 工藤淳子, 狭戸尾真梨子, 齋藤百合子, 浜田菜穂子, 船橋浩一, 中路重之
  • Volume: 20(2)
  • Pages: 140-143
• [Journal Article] (2010)
  • Author(s): 渡邉清誉, 梅田孝, 有賀玲子, 谷川涼子, 浜野学, 松田基子, 松本秀彦, 中路重之
  • Journal Title: 腸内細菌による肥満への影響体力・栄養・免疫学雑誌 Volume: 20(2) Pages: 137-139
• [Presentation] 自記式睡眠評価とメタボリックシンドロームの関係 (2012)
  • Author(s): 大久保礼由,松坂方士,佐藤真樹,小嶋新太,兼板佳孝,大井田隆,梅田孝,中路重之
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都市
  • Year and Date: 20120000
• [Presentation] 腸内の乳酸菌と肥満の関連について (2012)
  • Author(s): 渡邉清誉,高橋一平,本田勝義,米田勝朗,三輪孝士,和田尚子,伊東良,上谷英史,梅田孝,中路重之
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都市
  • Year and Date: 20120000
• [Presentation] 腸内細菌叢と肥満との関係 (2011)
  • Author(s): 渡邉清誉,梅田孝,黒岩純,竹石洋介,田中充洋,松田基子,中路重之
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 20110000
• [Presentation] 腸内細菌と体脂肪の関連について (2011)
  • Author(s): 渡邉清誉,本田勝義,矢野智彦,米田勝朗,三輪孝士,和田尚子,伊東良,小川武志,梅田孝,中路重之
  • Organizer: 第20回体力・栄養・免疫学会
  • Place of Presentation: 東京都
  • Year and Date: 20110000
• [Presentation] 動脈硬化の独立した危険因子としての睡眠時間、自覚的睡眠の質の検討 (2011)
  • Author(s): 松坂方士,大久保礼由,檀上和真,高橋一平,梅田孝,兼板佳孝,大井田隆,中路重之
  • Organizer: 第70回日本公衆衛生学会総会
  • Place of Presentation: 秋田市
  • Year and Date: 20110000
• [Presentation] 一般住民の腸管内メタン産生と腸内細菌に関する研究 (2010)
  • Author(s): 長谷部達也,梅田孝,工藤淳子,狭戸尾真梨子,齋藤百合子,浜田菜穂子,船橋浩一,中路重之
  • Organizer: 第20回体力・栄養・免疫学会
  • Place of Presentation: 弘前市
  • Year and Date: 20100000
• [Presentation] 呼気中水素およびメタン濃度と腸内細菌叢の関連に関する研究 (2010)
  • Author(s): 長谷部達也,梅田孝,佐藤弘道,鈴木隆,谷本歩実,徳田糸代,徳安秀正,山本博,矢野智彦,中路重之
  • Organizer: 第80回日本衛生学会学術総会
  • Place of Presentation: 仙台市
  • Year and Date: 20100000