2011 Fiscal Year Final Research Report
Elucidation of mechanisms for protective effects of NO-generating agents against radiation
| Project/Area Number |
21651019
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | University of Fukui |
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Principal Investigator |
MATSUMOTO Hideki 福井大学, 高エネルギー医学研究センター, 准教授 (40142377)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 防護 / 一酸化窒素 |
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| Research Abstract |
Among the drugs for angina pectoris and hyperpiesia, sodium nitroprusside, isosorbide dinitrate, nitroglycerin, nicorandil, nipradilol were selected and examined for the presence of protective activities against X-rays-induced injury and toxicities using normal human fibroblasts, AG1522cells. All drugs possessed protective activities against radiation and indicated non-toxicities up to 3μM.
Furthermore, 5drugs were examined for the presence of protective activities against X-rays, mixed radiation(γ-rays and neutron) or neutron-induced injury and toxicities using normal mice(jcl : ICR, 8weeks old, male). All drugs were non-toxicities. However, Sodium nitroprusside only possessed protective activities against the injury induced by X-rays and it is due to promoting of restoration of hematopoietic and immune functions. Sodium nitroprusside was effective in the injury induced by mixed radiation, but not by neutrons alone.
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