Pilot study of analytical methods for the lower-chlorinated hydroxylated PCBs in the blood and brain of wildlife

2011 Fiscal Year Final Research Report

• Project/Area Number: 21651024
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Ehime University
• Principal Investigator: TANABE Shinsuke 愛媛大学, 沿岸環境科学研究センター, 教授 (60116952)
• Co-Investigator(Renkei-kenkyūsha): NOMIYAMA Kei 愛媛大学, 沿岸環境科学研究センター, 助教 (30512686) ; TAKASUGA Takumi 愛媛大学, 沿岸環境科学研究センター, 客員教授 (10451379)
• Project Period (FY): 2009 – 2011
• Keywords: 環境分析 / 有害化学物質 / PCBs / 代謝活性化

Research Abstract

The present study investigated the accumulation features of lower-chlorinated OH-PCBs in the blood and brain of cetaceans and transitional state of these OH-PCBs into the brain was clarified. Optimization of the extraction and clean-up method was developed for the analyses of lower-chlorinated OH-PCBs in the blood and brain of cetaceans. OH-PCBs tend to accumulate at higher levels in brain than in blood, yet no statistical significance was observed. Congener profile of OH-PCBs in brain was different from that in blood ; penta-chlorinated congeners were dominant in the brain. Thus, specific transfer and accumulation of penta-chlorinated congeners in brain was suspected.

Research Products

• [Journal Article] Different Profiles of Anthropogenic and Naturally Produced Organohalogen Compounds in Serum from Residents Living near a Coastal Area and E-waste Recycling Workers in India (2012)
  • Author(s): Eguchi A., Nomiyama K., Devanathan G., Subramanian A., Bulbule K. A., Parthasarathy P., Takahashi S., Tanabe S.
  • Journal Title: Environment International Volume: (in press)
  • Peer Reviewed
• [Journal Article] Organohalogen compounds and their metabolites in the blood of Japanese amberjack(Seriola quinqueradiata) and scalloped hammerhead shark (2011)
  • Author(s): Nomiyama K., Uchiyama Y., Horiuchi S., Eguchi A., Mizukawa H., Horai Hirata S., Shinohara R., Tanabe S.
  • Journal Title: Chemosphere Volume: 85 Pages: 315-321
• [Journal Article] Anthropogenic and naturally occurring polybrominated phenolic compounds in the blood of cetaceans stranded along Japanese coastal waters (2011)
  • Author(s): Nomiyama K., Eguchi A., Mizukawa H., Ochiai M., Murata S., Someya M., Isobe T., Yamada T. K., Tanabe S.
  • Journal Title: Environmental Pollution Volume: 159 Pages: 3364-3373
  • Peer Reviewed
• [Journal Article] Polychlorinated biphenyls and their hydroxylated metabolites(OH-PCBs) in the blood of toothed and baleen whales stranded along Japanese coastal waters (2010)
  • Author(s): Nomiyama K., Murata S., Kunisue T., Yamada T. K., Mizukawa H., Takahashi S., Tanabe S.
  • Journal Title: Environmental Science & Technology Volume: 44 Pages: 3732-3738
  • Peer Reviewed
• [Presentation] Accumulation of halogenated phenolic compounds in small toothed whales (2011)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuishi, T., Amano, M. and Tanabe, S.
  • Organizer: The 6^<th> Global COE International Symposium on Advanced Studies by Young Scientists on Environmental Pollution and Ecotoxicology(Abstract Book)
  • Place of Presentation: Matsuyama, Japan
  • Year and Date: 20110800
• [Presentation] Accumulation of anthropogenic and natural origin organohalogen compounds in three porpoise species (2011)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuishi, T., Amano, M. and Tanabe, S.
  • Organizer: 31^<st> International Symposium on Halogenated Persistent Organic Pollutants(DIOXIN 2011)(Abstract Book)
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 20110800
• [Presentation] ネズミイルカ科の小型鯨類に残留する人為起源および天然起源ハロゲン化フェノール類の蓄積特性 (2011)
  • Author(s): 落合真理・野見山桂・磯部友彦・山田格・田島木綿子・松石隆・天野雅男・田辺信介
  • Organizer: 第20回環境化学討論会(講演要旨集)
  • Place of Presentation: 熊本市
  • Year and Date: 20110700
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.6 (2012)
  • Author(s): Mizukawa, H., Nomiyama, K., Nakatsu, S., Yachimori, S., Hayashi, T., Tashiro, Y., Yamamoto, M. and Tanabe, S.
  • Total Pages: 203-210
  • Publisher: TERRAPUB, Tokyo, Japan(Kawaguchi, M., Misaki, K., Sato, H., Yokokawa, T., Itai, T., Tue, N. M., Ono, J. and Tanabe, S.(Eds))
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.6 (2012)
  • Author(s): Ochiai, M., Nomiyama, K., Isobe, T., Yamada, T. K., Tajima, Y., Matsuishi, T., Amano, M. and Tanabe, S.
  • Total Pages: 187-192
  • Publisher: TERRAPUB, Tokyo, Japan(Kawaguchi, M., Misaki, K., Sato, H., Yokokawa, T., Itai, T., Tue, N. M., Ono, J. and Tanabe, S.(Eds))
• [Book] Interdisciplinary Studies on Environmental Chemistry, Vol.4 (2010)
  • Author(s): Nomiyama, K., Murata, S., Kunisue, T., Yamada, T. K., Mizukawa, H., Takahashi, S. and Tanabe, S.
  • Total Pages: 67-74
  • Publisher: TERRAPUB, Tokyo, Japan(Isobe, T., Nomiyama, K., Subramanian and Tanabe, S.(Eds))
• [Remarks]
  • URL: http://ehime-u.cyber-earth.jp/g-coe2007/jp/index.aspx