2011 Fiscal Year Final Research Report
EffectsofperinatalexposuretobisphenolAonmotorfunctionandaginginrats
| Project/Area Number |
21651025
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
SHINKAI Tadashi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (10154387)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 老化 / ビスフェノールA / 内分泌かく乱物質 |
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| Research Abstract |
The bisphenol A represents a family of ubiquitous environmental pollutants and are well known as environmental endocrine disruptors. It changes multiple endocrine systems in the living body. Moreover, there is a suggestive consideration that the bisphenol A may have influence on aging. In order to investigate the lifespan associated with the bisphenol A, we gave a sin gle subcutaneous injection of bisphenol A to pregnant Wistar rats on gestational day 19 and studied the effects of a relatively low dose of bisphenol A on the offspring. The plasma concentration of thyroxin and gonadal hormone decreased in male and female by perinatal bisphenol A exposure, on the other hand the incidence of mammary tumors increased in female. The bisphenol A may play an important role in both hypogenitalism and hypothyroidism. The experimental study of lifespan is still continuing, the result obtained shows tendency of a slight decrease in male and female. Our finding suggests that the bisphenol A may induce modulation of endocrinologial function and promote aging.
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[Journal Article] Hypergravity specifically effects h ead formation in the Xenopus embryos raised under hypergravity condition2012
Author(s)
Yanagisawa M., furuno M., Watanabe M., Kashiwagi K., Hanada H., Shinkai T., Yoshitome S., Kubo H., Sakai M., Fujii H., Suzuki K., Yamashita M. and Kashiwagi A
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Journal Title
Space Utiliz. Res
Volume: 28(in press)
Peer Reviewed
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[Journal Article] Involvement of murine B-1, 4-galactosyltransferase V in lactosylceramide biosynthesis2010
Author(s)
Kumagai, T., Sato, T., Kobayashi, Y., Zhou, D., Shinkai, T., Hayakawa, S. and Furukawa, K
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Journal Title
Glycoconj. J
Volume: 27
Pages: 685-695
Peer Reviewed
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[Journal Article] 両生類の生活環に対する強磁場の影響-初期発生の形態学的および分子生物学的解析2010
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柏木昭彦,柏木啓子,坂尾智美,古野伸明,藤原好恒,谷本能文,山下雅道,渡部稔,新海正,吉留賢,久保英夫,坂井雅夫,藤井博匡,柳澤誠,花田秀樹,内藤富夫
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Journal Title
Space Utilization Res
Volume: 26
Pages: 232-235
Peer Reviewed
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[Presentation] 両生類の行動に対する強磁場制御による微少および過重力環境の影響2012
Author(s)
藤原好恒,柏木啓子,中川真依,新海正,柳澤誠,花古野伸明,田秀樹,鈴木賢一,勝賢二郎,山下雅道,山本卓,谷本能文,柏木昭彦
Organizer
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Year and Date
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Author(s)
柳澤誠,古野伸明,渡部稔,柏木啓子,花田秀樹,新海正,吉留賢,久保英夫,坂井雅夫,藤井博匡,鈴木賢一,山下雅道,柏木昭彦
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宇宙利用シンポジウム(第28回)
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Year and Date
20120123-24
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Author(s)
柳澤誠,古野伸明,渡部稔,柏木啓子,花田秀樹,新海正,吉留賢,久保英夫,坂井雅夫,藤井博匡,鈴木賢一,山下雅道,柏木昭彦
Organizer
日本動物学会第82回大会
Place of Presentation
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Year and Date
20110921-23
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[Presentation] 過重力によって生じたアフリカツメガエル初期胚の頭部形成異常の解析II2011
Author(s)
柳澤誠,古野伸明,渡部稔,柏木啓子,花田秀樹,新海正,吉留賢,久保英夫,坂井雅夫,藤井博匡,山下雅道,柏木昭彦
Organizer
宇宙利用シンポジウム(第27回)
Place of Presentation
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Year and Date
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[Presentation] 両生類の生活環に対する強磁場の影響-初期発生の形態学的および分子生物学的解析2010
Author(s)
柏木昭彦,柏木啓子,坂尾智美,古野伸明,藤原好恒,谷本能文,山下雅道,渡部稔,新海正,吉留賢,久保英夫,坂井雅夫,藤井博匡,柳澤誠,花田秀樹,内藤富夫
Organizer
宇宙利用シンポジウム(第26回)
Place of Presentation
相模原市(神奈川)
Year and Date
20100125-26
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