2011 Fiscal Year Final Research Report
Selective labeling, imaging, and functional control of living cells
Project/Area Number |
21651096
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Living organism molecular science
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Research Institution | Osaka University |
Principal Investigator |
FUKASE Koichiz 大阪大学, 大学院・理学研究科, 教授 (80192722)
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Project Period (FY) |
2009 – 2011
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Keywords | 蛍光標識 / 蛍光イメージング / PETイメージング / 複合体糖鎖 / 癌細胞 / 転移 |
Research Abstract |
New less-invasive labeling of living cells was established and applied to imaging studies based on 6π-azalectrocyclization reaction. The efficient method for the conjugation of bio-molecules was also developed using 6π-azalectrocyclization. A new antitumor molecule was developed by using template-assisted conjugation.
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Research Products
(72 results)
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[Journal Article] Cell surface biotinylation by azaelectrocyclization and versatile approach for living cell labeling, Bioorg2012
Author(s)
Tanaka, K., Yokoi, S., Morimoto, K., Iwata, T., Nakamoto, Y., Nakayama, K., Koyama, K., Fujiwara, T., Fukase, K
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Journal Title
Med. Chem
Volume: 0
Pages: 1865-1868
Peer Reviewed
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[Journal Article] Auxiliary-directed oxidation of ursolic acid by' Ru'-porphyrins : chemical modulation of cytotoxicity against tumor cell lines2012
Author(s)
Tanaka, K., Mazumder, K., Siwu, E. R. O., Nozaki, Satoshi, Watanabe, Y., Fukase, K
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Journal Title
Tetrahedron Lett
Volume: 53
Pages: 1756-1759
Peer Reviewed
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[Journal Article] Template-assisted and self-activating clicked peptide as a synthetic mimic of the SH2 domain2011
Author(s)
Tanaka, K., Shirotsuki, S., Kageyama, C., Tahara, T., Nozaki, S., Siwu, E. R. O., Iwata, T., Tamura, S., Douke, S., Murakami, N., Onoe, H., Watanabe, Y., Fukase, K
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Journal Title
ACS Chem. Biol
Volume: 7
Pages: 637-644
Peer Reviewed
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[Journal Article] Non-invasive imaging of dendrimer-type N-glycan clusters : in vivo dynamics dependence on oligosaccharide structure, Chen, C. W., Paulson, C. J., Watanabe, Y., Fukase, K2010
Author(s)
Tanaka, K., Siwu, R. O. E., Minami, K., Hasegawa, K., Nozaki, S., Kanayama, Y., Koyama, K
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Journal Title
Angew. Chem. Int. Ed.
Volume: 49
Pages: 8195-8200
Peer Reviewed
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[Journal Article] A combined 6π-azaelectrocyclization/ staudinger approach to protein & cell engineering : non-invasive tumor targeting by N-Glycan-engineered lymphocytes2010
Author(s)
Tanaka, K., Minami, K., Tahara, T., Siwu, E. R. O., Koyama, K., Nozaki, S., Onoe, H., Watanabe, Y., Fukase, K.
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Journal Title
J. Carbohydr. Chem.
Volume: 29
Pages: 118-132
Peer Reviewed
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[Journal Article] Electrocyclization-based labeling allows efficient in Vivo imaging of cellular trafficking2010
Author(s)
Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E. R. O., Nozaki, S.; Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., Fukase, K.
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Journal Title
ChemMedChem
Pages: 841-845
Peer Reviewed
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[Journal Article] Library-directed Solution-and Solid-phase Synthesis of 2, 4-Disubstituted Pyridines : One-pot Approach through 6. pi.-Azaelectrocyclization2009
Author(s)
Sakaguchi, T., Kobayashi, T., Hatano, S., Tsuchikawa, H., Fukase, K., Tanaka, K., and Katsumura, S.
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Journal Title
Chemistry-An Asian Journal
Volume: 4(10)
Pages: 1573-1577
Peer Reviewed
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[Presentation] Synthetic Approach for Elucidating Glycan Codes2010
Author(s)
Koichi Fukase, Yukari Fujimoto, Katsunori Tanaka
Organizer
The 5th International Conference on Cutting-Edge Organic Chemistry in Asia(ICCEOCA-5)/ The 1st New phase International Conference on Cutting-Edge Organic Chemistry in Asia(NICCEOCA-1)
Place of Presentation
Ambassador Hotel at Hsinchu, Taiwan
Year and Date
20101107-11
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[Presentation] Remarkable Structural Dependency of N-Glycan Clusters on In、Vivo Dynamics2010
Author(s)
E. R. Siwu, K. Tanaka, K. Minami, K. Hasegaw a, S. Nozaki, Y. Kanayama, K. Koyama, W. C. Chen, J. Paulson, Y. Watanabe, K. Fukase
Organizer
The 25th International Carbohydrate Symposium(ICS2010)
Place of Presentation
Makuhari Messe(Chiba)
Year and Date
20100801-06
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[Presentation] Non-Invasive In Vivo Imaging of N-Glycans2010
Author(s)
Katsunori Tanaka and Koic hi Fukase
Organizer
International Symposium on Organelle Networks : Interface among Infection-Immunity
Place of Presentation
Cell Biology and Glycobio logy, Senri Life Science Center(Osaka)
Year and Date
20100412-13
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[Presentation] Self-Activating" & Induced-Fit" Approach to Peptidyl Mimic of Grb2-SH2 Domain2010
Author(s)
K. Tanaka, T. Iwata, S. Shirotsuki, C. Kageyama, T. Tahara, S Nozaki, E. R. O. Siwu, S. Tamura, S. Douke, N. Murakami, H. Onoe, Y. Watanabe, K. Fukase
Organizer
5^<th> International Peptide Symposium
Place of Presentation
Kyoto International Conference Center
Year and Date
2010-12-06
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[Presentation] Azaelectrocyclization-Based Labeling & Engineering Allow Non-Invasive Imaging of Cellular Trafficking and Tumor Targeting by Lymphocytes2010
Author(s)
Katsunori Tanaka, Kaori Minami, Tsuyoshi Tahara, Yohei Fujii, Eric, R. O. Siwu, Satoshi Nozaki, Hirotaka Onoe, Satomi Yokoi, Koichi Koyama, Yasuyoshi Watanabe, and Koichi Fukase
Organizer
World Molecular Imaging Congress(WMIC)
Place of Presentation
Kyoto International Conference Center
Year and Date
2010-09-09
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[Presentation] In vivo imaging of glycoproteins and glycoclusters2009
Author(s)
Koichi Fukase, Katsunori Tanaka, Tatsuro Masuyama, Kaori Minami, Eric R. O. Siwu, Koki Hasegawa, Tsuyoshi Tahara, Hiroshi Mizuma, Yasuhiro Wada, Yasuyoshi Watanabe
Organizer
2nd Switzerland. Japan Biomolecular Chemistry Symposium
Place of Presentation
Tokyo Univ.
Year and Date
20090911-12
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[Presentation] Fast Labeling of Lysines via 6π-Azaelectrocyclization : Application to Pet Imaging of Glycoproteins and Glycociusters2009
Author(s)
K. Fukase, K. Tanaka, T. Masuyama, K. Minami, E. R. O. Siwu, K. Hasegawa, T. Tahara, H. Mizuma, Y. Wada, Y. Watanabe
Organizer
15th European Carbohydrate Symposium(eurocarb15)
Place of Presentation
Vienna, Austria
Year and Date
20090719-24
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