2011 Fiscal Year Final Research Report
Development of micelle and vesicle based on amphiphilic compound bearing various sugar moieties and estimation of their cell recognition abilities.
| Project/Area Number |
21655063
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemistry related to living body
|
|---|
| Research Institution | Wakayama University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 核酸 / 蛋白質 / 糖化学 / 自己組織化 |
|---|
| Research Abstract |
The purpose of this study is the development of stable micelle and/or vesicle based on amphiphilic compounds in order to apply them to the capsule for the drug delivery system(DDS). It is well-known that galactose selectively interacts with the cell on the surface of a liver. Thus, the amphiphilic compounds composed of galactose group as a hydrophilic moietry and various lipophilic moietyies were synthesized and the property of their aggregates were investigated. The glycoside bonds were formed on galactose using 2, 2-bis(octadecyloxymethyl)-1-propanol and 2-benzyloxymethyl-2, 2-bis(octadecyl-oxymethyl)-1-ethanol to give compounds 1 and 2, respectively. It was found by using the spectrophotometry and transmission electron microscope(TEM) that the aggregate of compound 1 has the vesicle structure, which includes an aqueous phase inside.
|
Research Products
(1 results)
