2011 Fiscal Year Final Research Report
Exploring molecular entities of innate immune system that changes through metamorphosis in starfish
| Project/Area Number |
21657063
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Evolutionary biology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 棘皮動物 / ヒトデ / 自然免疫 / 認識メカニズム / 個体発生 / 変態 / 間充織細胞 / 体腔細胞 |
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| Research Abstract |
In invertebrate, a comparative analysis of larval and adult innate immune system, from a perspective of ontology, has not been made. We revealed that the allorecognition capability of immune cells is acquired after metamorphosis in the immune system of the starfish, Asterina pectinifera. Although a global analysis comparing genes expression in the larval and the adult immune cells showed that the majority of immune-related gene is common to both cell types, a certain type of gene that suggests the alteration of immune recognition system was present in these common genes.
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