2011 Fiscal Year Final Research Report
The analysis of cell death mechanism that depended on newly isolated nucleolar GTP binding protein.
| Project/Area Number |
21658020
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied entomology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TSUNEIZUMI Kazuhide 独立行政法人理化学研究所, 松本分子昆虫学研究室, 専任研究員 (40280953)
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| Project Period (FY) |
2009 – 2011
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| Keywords | nucleostemin / apoptosis / cell death / ribosomal biogenesis / GTP binding protein |
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| Research Abstract |
In this study, I made clear that an intracellular signal-transducing pathway of dNS1 to cell death was independent from p53 and there was big difference in intracellular mechanism between vertebrate and Drosophila. I succeeded in the isolation of interactive factors to dNS1 and the screening for small molecular compounds that directly modulate the activity of dNS1.
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