2011 Fiscal Year Final Research Report
Study on the regulatory mechanism of thyroglobulin on thyroidal function by use of novel culture system of thyroid follicular cells
| Project/Area Number |
21659052
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 甲状腺 / 上皮細胞 / サイログロブリン / 極性培養 |
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| Research Abstract |
Thyroid hormones are synthesized in the thyroid follicles consist of thyroid epithelial cells. To examine the effects of thyroglobulin, the precursor molecule of thyroid hormones, on the function of thyroid, we established the functional gradient culture system composed of thyroid epithelial cells and endothelial cells. Using this system, we found that thyroglobulin stimulated the secretion of cathepsin K, one of the key enzymes of thyroid hormone synthesis, to the follicular side. This suggests that thyroglobulin directly regulates the thyroid hormone synthesis.
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