A new strategy to conquer obesity by use of a newly discovered neuropeptide GALP

2011 Fiscal Year Final Research Report

• Project/Area Number: 21659059
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Showa University
• Principal Investigator: SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
• Co-Investigator(Kenkyū-buntansha): KAGEYAMA Haruaki 昭和大学, 医学部, 助教 (00433839) ; TAKENOYA Fumiko 星薬科大学, 薬学部, 講師 (30234412)
• Project Period (FY): 2009 – 2011
• Keywords: GALP / 摂食調節 / 抗肥満療法 / エネルギー代謝 / ニューロンネットワーク

Research Abstract

GALP is known as a neuropeptide whish regulates feeding and energy metabolism but there is no reports to use of GALP for obese animals efficiently. In this study, we have established the intranasal infusion method of GALP for animals. We have studied obese animals such as ob/ob, db/db and DIO mice and we got the data that intranasal infusion of GALP was very effective on these animals to loose body weight and food intake. It is suggested that intranasal infusion of GALP is useful for obese people to conquer obesity and life-style related diseases in future.

Research Products

• [Journal Article] ガラニン様ペプチド(GALP)による摂食・代謝調節と肥満克服の新戦略 (2011)
  • Author(s): 影山晴秋、竹ノ谷文子、柴加奈子、塩田清二
  • Journal Title: 実験医学 Volume: 29(5) Pages: 67-72
• [Journal Article] Galanin-Like Peptide(GALP)の抗肥満効果について (2011)
  • Author(s): 竹ノ谷文子、影山晴秋、柴加奈子、塩田清二
  • Journal Title: 最新医学 Volume: 66(6月増刊号) Pages: 1487-1497
• [Journal Article] Expression and localization of the orexin-1 receptor(OX1R) after traumatic brain injury in mice (2011)
  • Author(s): Mihara Y, Dohi K, Yofu S, Nakamachi T, Ohtaki H, Shioda S, Aruga T
  • Journal Title: J Mol Neurosci Volume: 43(2) Pages: 162-168
  • Peer Reviewed
• [Journal Article] Galanin-like peptide : a key player in the homeostatic regulation of feeding and energy metabolism (2011)
  • Author(s): Shioda S, Kageyama H, Takenoya F, Shiba K
  • Journal Title: Int J Obes(Lond) Volume: 35(5) Pages: 619-628
  • Peer Reviewed
• [Journal Article] Decreased intake of sucrose solutions in orexin knockout mice (2011)
  • Author(s): Matsuo E, Mochizuki A, Nakayama K, Nakamura S, Yamamoto T, Shioda S, Sakurai T, Yanagisawa M, Shiuchi T, Minokoshi Y, Inoue T
  • Journal Title: J Mol Neurosci Volume: 43(2) Pages: 217-224
  • Peer Reviewed
• [Journal Article] Effect of intraperitoneal injection of curcumin on food intake in a goldfish model (2011)
  • Author(s): Kang KS, Yahashi S, Azuma M, Sakashita A, Shioda S, Matsuda K
  • Journal Title: J Mol Neurosci Volume: 45(2) Pages: 172-176
  • Peer Reviewed
• [Journal Article] Isolation and characterisation of two cDNAs encoding the neuromedin U receptor from goldfish brain (2011)
  • Author(s): Maruyama K, Kaiya H, Miyazato M, Konno N, Wakasugi T, Uchiyama M, Shioda S, Murakami N, Matsuda K
  • Journal Title: J Neuroendocrinol Volume: 23(3) Pages: 282-291
  • Peer Reviewed
• [Journal Article] Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche (2011)
  • Author(s): Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H
  • Journal Title: Cell Volume: 147(5) Pages: 1146-1158
  • Peer Reviewed
• [Journal Article] Neuropeptide Y in tiger puffer(Takifugu rubripes): distribution, cloning, characterization, and mRNA expression responses to prandial condition (2011)
  • Author(s): Kamijo M, Kojima K, Maruyama K, Konno N, Motohashi E, Ikegami T, Uchiyama M, Shioda S, Ando H, Matsuda K
  • Journal Title: Zoolog Sci Volume: 28(12) Pages: 882-890
  • Peer Reviewed
• [Journal Article] Neuropeptide W : a key player in the homeostatic regulation of feeding and energy metabolism (2010)
  • Author(s): Takenoya F, Kageyama H, Shiba K, Date Y, Nakazato M, Shioda S
  • Journal Title: Ann N Y Acad Sci Volume: 1200 Pages: 162-169
• [Journal Article] Distribution of neuropeptide W in the rat brain (2010)
  • Author(s): Takenoya F, Yagi M, Kageyama H, Shiba K, Endo K, Nonaka N, Date Y, Nakazato M, Shioda S
  • Journal Title: Neuropeptides Volume: 44(2) Pages: 99-106
  • Peer Reviewed
• [Journal Article] Relationship between alpha-melanocyte-stimulating hormone-and neuropeptide Y-containing neurons in the goldfish hypothalamus (2010)
  • Author(s): Kojima K, Amiya N, Kamijo M, Kageyama H, Uchiyama M, Shioda S, Matsuda K
  • Journal Title: Gen Comp Endocrinol Volume: 167(3) Pages: 366-372
  • Peer Reviewed
• [Journal Article] Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding (2010)
  • Author(s): Kageyama H, Takenoya F, Shiba K, Shioda S
  • Journal Title: Neuropeptides Volume: 44(2) Pages: 133-138
  • Peer Reviewed
• [Journal Article] Neuropeptide W : an anorectic peptide regulated by leptin and metabolic state (2010)
  • Author(s): Date Y, Mondal MS, Kageyama H, Ghamari-Langroudi M, Takenoya F, Yamaguchi H, Shimomura Y, Mori M, Murakami N, Shioda S, Cone RD, Nakazato M
  • Journal Title: Endocrinology Volume: 151(5) Pages: 2200-2210
  • Peer Reviewed
• [Journal Article] Localization of neuroendocrine regulatory peptide-1 and-2 in human tissues (2010)
  • Author(s): Matsuo T, Yamaguchi H, Kageyama H, Sasaki K, Shioda S, Minamino N, Nakazato M
  • Journal Title: Regul Pept Volume: 163(1-3) Pages: 43-48
  • Peer Reviewed
• [Journal Article] Galanin-like peptide and the regulation of feeding behavior and energy metabolism (2010)
  • Author(s): Shiba K, Kageyama H, Takenoya F, Shioda S
  • Journal Title: FEBS J Volume: 277(24) Pages: 5006-5013
  • Peer Reviewed
• [Journal Article] Neuroendocrine regulatory peptide-2 regulates feeding behavior via the orexin system in the hypothalamus (2010)
  • Author(s): Toshinai K, Yamaguchi H, Kageyama H, Matsuo T, Koshinaka K, Sasaki K, Shioda S, Minamino N, Nakazato M
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 299(3) Pages: E394-401
  • Peer Reviewed
• [Journal Article] Relationship between melanin-concentrating hormone-and neuropeptide Y-containing neurons in the goldfish hypothalamus (2009)
  • Author(s): Matsuda K, Kojima K, Shimakura S, Miura T, Uchiyama M, Shioda S, Ando H, Takahashi A
  • Journal Title: Comp Biochem Physiol A Mol Integr Physiol Volume: 153(1) Pages: 3-7
  • Peer Reviewed
• [Journal Article] Purification and properties of ghrelin from the intestine of the goldfish (2009)
  • Author(s): Miura T, Maruyama K, Kaiya H, Miyazato M, Kangawa K, Uchiyama M, Shioda S, Matsuda K
  • Journal Title: Carassius auratus Volume: 30(4) Pages: 758-765
  • Peer Reviewed
• [Journal Article] Neuronal relationship between orexin-A-and neuropeptide Y-induced orexigenic actions in goldfish (2009)
  • Author(s): Kojima K, Kamijo M, Kageyama H, Uchiyama M, Shioda S, Matsuda K
  • Journal Title: Neuropeptides Volume: 43(2) Pages: 63-71
  • Peer Reviewed
• [Journal Article] Effects of gastric vagotomy on visceral cell proliferation induced by ventromedial hypothalamic lesions : role of vagal hyperactivity (2009)
  • Author(s): Kintaka Y, Osaka T, Suzuki Y, Hashiguchi T, Niijima A, Kageyama H, Takenoya F, Shioda S, Inoue S
  • Journal Title: J Mol Neurosci Volume: 38(3) Pages: 243-249
  • Peer Reviewed
• [Journal Article] Leptin modulates ACAT1 expression and cholesterol efflux from human macrophages (2009)
  • Author(s): Hongo S, Watanabe T, Arita S, Kanome T, Kageyama H, Shioda S, Miyazaki
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 297(2) Pages: E474-482
  • Peer Reviewed
• [Journal Article] Neuromedin U-induced anorexigenic action is mediated by the corticotropin-releasing hormone receptor-signaling pathway in goldfish (2009)
  • Author(s): Maruyama K, Wada K, Ishiguro K, Shimakura S, Wakasugi T, Uchiyama M, Shioda S, Matsuda K
  • Journal Title: Peptides Volume: 30(12) Pages: 2483-2486
  • Peer Reviewed
• [Journal Article] Melanin-concentrating hormone reduces somatolactin release from cultured goldfish pituitary cells (2009)
  • Author(s): Tanaka M, Azuma M, Nejigaki Y, Saito Y, Mizusawa K, Uchiyama M, Takahashi A, Shioda S, Matsuda K
  • Journal Title: J Endocrinol Volume: 203(3) Pages: 389-398
  • Peer Reviewed
• [Journal Article] Hypothalamic orexin stimulates feeding-associated glucose utilization in skeletal muscle via sympathetic nervous system (2009)
  • Author(s): Shiuchi T, Haque MS, Okamoto S, Inoue T, Kageyama H, Lee S, Toda C, Suzuki A, Bachman ES, Kim YB, Sakurai T, Yanagisawa M, Shioda S, Imoto K, Minokoshi Y
  • Journal Title: Cell Metab Volume: 10(6) Pages: 466-480
  • Peer Reviewed
• [Presentation] 摂食調節神経ペプチドの機能形態学的研究 (2012)
  • Author(s): 竹ノ谷文子、影山晴秋、塩田清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-27
• [Presentation] 遺伝子工学的手法を用いたGALPニューロンの求心路の同定 (2012)
  • Author(s): 影山晴秋、細野知彦、荒田悟、竹ノ谷文子、塩田清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-27
• [Presentation] ストレス経路を介したニューロペプチドW(NPW)の摂食抑制作用 (2012)
  • Author(s): 遠藤慶、竹ノ谷文子、影山晴秋、塩田清二
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-27
• [Presentation] 肝臓に対するガラニン様ペプチド(GALP)と自発運動の相互作用 (2012)
  • Author(s): 伊藤和夫、影山晴秋、竹ノ谷文子、塩田清二
  • Organizer: 第117回日本解剖学会総会
  • Place of Presentation: 甲府
  • Year and Date: 2012-03-27
• [Presentation] 肥満動物モデルへのGALPの点鼻投与による摂食調節と抗肥満効果 (2012)
  • Author(s): 影山晴秋、野木孝准、竹ノ谷文子、平野勉・塩田清二
  • Organizer: 第26回日本糖尿病・肥満動物学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-02-17
• [Presentation] マウスの自発運動によるニューロペプチドWの摂食作用への影響 (2012)
  • Author(s): 竹ノ谷文子、影山晴秋、遠藤慶、伊藤和夫、塩田清二
  • Organizer: 第26回日本糖尿病・肥満動物学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-02-17
• [Presentation] Anti-obese effect of intranasal infusion of GALP in obese mice (2011)
  • Author(s): Kageyama H, Takenoya F, Shioda S
  • Organizer: Satellite Symposium of the 20th Annual Meeting of The Israel Society for Neuroscience～ Basic and Clinical Research of GPCRs～
  • Place of Presentation: Eilat, Israel
  • Year and Date: 2011-12-13
• [Presentation] Galanin-like peptide(GALP) facilitates energy metabolism via the astrocytes in the brain (2011)
  • Author(s): Kageyama H, Wang L, Osaka T, Ito K, Takenoya F, Shioda S
  • Organizer: Satellite Symposium of the 20th Annual Meeting of The Israel Society for Neuroscience～ Basic and Clinical Research of GPCRs～
  • Place of Presentation: Eilat, Israel
  • Year and Date: 2011-12-13
• [Presentation] Effect of neuropeptide W(NPW) on feeding regulation with voluntary exercise (2011)
  • Author(s): Takenoya F, Endo K, Kageyama H, Shioda S
  • Organizer: Satellite Symposium of the 20th Annual Meeting of The Israel Society for Neuroscience～ Basic and Clinical Research of GPCRs～
  • Place of Presentation: Eilat, Israel
  • Year and Date: 2011-12-13
• [Presentation] The anti-obese effects by intranasal administration of GALP in mice (2011)
  • Author(s): Kageyama H, Takenoya F, Kang K, Shioda S
  • Organizer: 41st Annual meeting Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-11-12
• [Presentation] ガラニン様ペプチド(GALP)点鼻投与による肥満克服の新戦略 (2011)
  • Author(s): 柴加奈子、影山晴秋、野中直子、竹ノ谷文子、塩田清二
  • Organizer: 第25回日本糖尿病肥満動物学会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-05
• [Presentation] ガラニン様ペプチドの点鼻投与による肥満症軽減の基盤研究 (2011)
  • Author(s): 影山晴秋、塩田清二
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
  • Year and Date: 2011-09-23
• [Presentation] グレリンとGLP-1の摂食調節関連 (2011)
  • Author(s): 十枝内厚次、塩田清二、新島旭、中里雅光
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
  • Year and Date: 2011-09-23
• [Presentation] 肥満マウスにおけるガラニン様ペプチド(GALP)点鼻投与による抗肥満効果 (2011)
  • Author(s): 影山晴秋、竹ノ谷文子、姜奇成、塩田清二
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
  • Year and Date: 2011-09-23
• [Presentation] ニューロペプチドW(NPW)の摂食抑制作用による自発運動の影響 (2011)
  • Author(s): 竹ノ谷文子、影山晴秋、塩田清二
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路
  • Year and Date: 2011-09-23
• [Presentation] 神経ペプチドW(NPW)の視床下部-下垂体-副腎系を介した摂食抑制機構について (2011)
  • Author(s): 影山晴秋、竹ノ谷文子、塩田清二
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] ペプチド点鼻投与による肥満克服 (2011)
  • Author(s): 竹ノ谷文子、影山晴秋、琉子友男、山本憲志、塩田清二
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 摂食調節における消化管由来ペプチドの相互連関 (2011)
  • Author(s): 十枝内厚次、ワイズザベッド、塩田清二、新島旭、中里雅光
  • Organizer: 第66回日本体力医学会大会
  • Place of Presentation: 下関
  • Year and Date: 2011-09-17
• [Presentation] 自発運動による神経ペプチドWの摂食作用への影響 (2011)
  • Author(s): 竹ノ谷文子、影山晴秋、琉子友男、山本憲志、塩田清二
  • Organizer: 第19回日本運動生理学会大会
  • Place of Presentation: 徳島
  • Year and Date: 2011-08-26
• [Presentation] Effect of intranasal infusion of GALP(galanin-like peptide) on feeding and body weight regulation (2011)
  • Author(s): Takenoya F, Shiba K, Kageyama H, Yamamoto N, Ryushi T, Shioda S
  • Organizer: 16th Annual Congress of the European College of Sport Science
  • Place of Presentation: Liverpool, UK
  • Year and Date: 2011-07-09
• [Presentation] 摂食調節ペプチドGALPによる肥満克服の新戦略 (2011)
  • Author(s): 影山晴秋、柴加奈子、竹ノ谷文子、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] マウスにおけるガラニン様ペプチド(GALP)点鼻投与による抗肥満効果 (2011)
  • Author(s): 柴加奈子、影山晴秋、野中直子、竹ノ谷文子、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] 摂食調節におけるニューロペプチドW(NPW)のニューロンネットワーク機構 (2011)
  • Author(s): 竹ノ谷文子、影山晴秋、柴加奈子、遠藤慶、加藤佐知、塩田清二
  • Organizer: 第88回日本生理学会大会・第116回日本解剖学会総会・全国学術集会合同大会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-28
• [Presentation] Anorexigenic effect of intranasal GALP on feeding behavior in obese mice (2010)
  • Author(s): Shiba K, Kageyama H, Nonaka N, Endo K, Takenoya F, Shioda S
  • Organizer: Official satellite symposium of the 14th International Congress of Endocrinology(ICE2010)(GPCR2010)
  • Place of Presentation: Kyoto
  • Year and Date: 20100300
• [Presentation] Neuropeptide W : a key player in the regulation of feeding (2010)
  • Author(s): Takenoya F, Kageyama H, Shiba K, Endo K, Ryushi T, Date Y, Nakazato M, Shioda S
  • Organizer: The 40th Annual Meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, CA
  • Year and Date: 2010-11-13
• [Presentation] 摂食調節ペプチドGALPの摂食調節とエネルギー代謝調節機構(シンポジスト) (2010)
  • Author(s): 影山晴秋、塩田清二
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 前橋
  • Year and Date: 2010-10-01
• [Presentation] New peptides in the regulation of feeding and metabolism (2010)
  • Author(s): Shioda S, Takenoya F, Shiba K, Kageyama H
  • Organizer: The 18th International symposium on regulatory peptides
  • Place of Presentation: Belfast, UK
  • Year and Date: 2010-09-05
• [Presentation] Feeding regulation and energy metabolism in the brin (2010)
  • Author(s): Shioda S, Takenoya F, Shiba K, Kageyama H
  • Organizer: 25th Conference of European Comparative Endocrinologists
  • Place of Presentation: Pecs, Hungary
  • Year and Date: 2010-08-31
• [Presentation] ガラニン様ペプチド(GALP)の点鼻投与法による肥満解消の試み (2010)
  • Author(s): 竹ノ谷文子、琉子友男、山本憲志、塩田清二
  • Organizer: 第18回日本運動生理学会
  • Place of Presentation: 鹿児島
  • Year and Date: 2010-07-31
• [Presentation] Neuronal network of neuropeptide W(NPW)-containing neurons in feeding regulation (2010)
  • Author(s): Takenoya F, Kageyama H, Shiba K, Date Y, Nakazato M, Shioda S
  • Organizer: XI International Congress of Obesity(ICO2010)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-07-16
• [Presentation] Feeding regulation by intranasal administration of GALP in obese mice (2010)
  • Author(s): Shiba K, Kageyama H, Nonaka N, Endo K, Takenoya F, Shioda S
  • Organizer: XI International Congress of Obesity(ICO2010)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-07-12
• [Presentation] A key player in the homeostatic regulation of feeding and energy metabolism (2010)
  • Author(s): Shioda S : Galanin-like peptide(GALP)
  • Organizer: Satellite Symposium of ICO2010～ Regulation of Feeding and Energy Metabolism by the Brain～
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-07-11
• [Presentation] Morphological analysis of galanin-like peptide(GALP)-producing cells using a line of transgenic mice that expresses fluorescent protein under the control of mouse transcription regulatory regions of GALP (2010)
  • Author(s): Kageyama H, Arata S, Hosono T, Takenoya F, Shiba K, Shioda S
  • Organizer: XI International Congress of Obesity(ICO2010)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2010-07-11
• [Presentation] Interaction between neuropeptide W(NPW)-and feeding regulatory peptide-containing neurons in rat brain (2010)
  • Author(s): Takenoya F, Kageyama H, Shiba K, Date Y, Nakazato M, Shioda S
  • Organizer: Official satellite symposium of the 14th International Congress of Endocrinology(ICE2010)(GPCR2010)
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-30
• [Presentation] 末梢臓器におけるガラニン様ペプチド(GALP)の分布局在 (2010)
  • Author(s): 影山晴秋、柴加奈子、竹ノ谷文子、遠藤慶、加藤佐知、荒田悟、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-28
• [Presentation] ラット視床下部におけるニューロペプチドWニューロンと摂食調節物質ニューロンの免疫電顕的観察 (2010)
  • Author(s): 竹ノ谷文子、影山晴秋、柴加奈子、加藤佐知、伊達紫、中里雅光、塩田清二
  • Organizer: 第115回日本解剖学会総会・全国学術集会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-28
• [Presentation] 視床下部における神経ペプチドの摂食調節ニューロンネットワーク (2010)
  • Author(s): 影山晴秋、竹ノ谷文子、柴加奈子、塩田清二
  • Organizer: 第42回神経解剖懇話会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-03-27
• [Presentation] Feeding regulation by GALP(Symposist) (2010)
  • Author(s): Kageyama H, Takenoya F, Shiba K, Shioda S
  • Organizer: Official satellite symposium of the 14th International Congress of Endocrinology(ICE2010)(GPCR2010)
  • Place of Presentation: Kyoto
  • Year and Date: 2010-03-26
• [Presentation] 神経ペプチドによる食欲・エネルギー代謝調節 (2009)
  • Author(s): 塩田清二
  • Organizer: 日本顎口腔機能学会第43回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2009-11-28
• [Presentation] Neuronal circuits of ghrelin involved in feeding regulation(Invited lecture) (2009)
  • Author(s): Shioda S, Kageyama H, Shiba K, Takenoya F
  • Organizer: 2009 International Symposium on Ghrelin
  • Place of Presentation: Tokyo
  • Year and Date: 2009-11-18
• [Presentation] Efficacy of intranasal GALP for feeding regulation in mouse (2009)
  • Author(s): Shiba K, Kageyama H, Nonaka N, Takenoya F, Shioda S
  • Organizer: APIPS 2009(3rd Asia-Pacific International Peptide Symposium)
  • Place of Presentation: Jeju Island, Korea
  • Year and Date: 2009-11-08
• [Presentation] 摂食調節に機能する新規神経ペプチドの発見 (2009)
  • Author(s): 十枝内厚次、塩田清二、中里雅光
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: 浜松
  • Year and Date: 2009-10-10
• [Presentation] 視床下部腹内側核に存在する摂食関連ペプチド;ニューロペプチドWの作用機構に関する研究 (2009)
  • Author(s): 伊達紫、塩田清二、中里雅光
  • Organizer: 第30回日本肥満学会
  • Place of Presentation: 浜松
  • Year and Date: 2009-10-09
• [Presentation] Morphological analysis of galanin-like peptide(GALP)-producing cells using transgenic mice that express fluorescent protein driven by the transcription regulatory regions of mouse GALP (2009)
  • Author(s): Kageyama H, Arata S, Hosono T, Takenoya F, Shiba K, Shioda S
  • Organizer: Yakushima 2009(Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 2009-10-02
• [Presentation] Distribution and localization of neuropeptide W-containing neurons in the rat brain (2009)
  • Author(s): Takenoya F, Kageyama H, Shiba K, Date Y, Nakazato M, Shioda S
  • Organizer: Yakushima 2009(Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 2009-10-02
• [Presentation] Effect of intranasal administration of GALP on feeding regulation in mouse (2009)
  • Author(s): Shiba K, Kageyama H, Nonaka N, Endo K, Takenoya F, Shioda S
  • Organizer: Yakushima 2009(Satellite Symposium of the 9th International Symposium on VIP, PACAP and Related Peptides) Phylogenetic Aspects of Neuropeptides-from Invertebrates to Humans
  • Place of Presentation: Yakushima, Kagoshima
  • Year and Date: 2009-10-02
• [Presentation] 抗肥満ペプチドの点鼻投与法による肥満解消の試み (2009)
  • Author(s): 竹ノ谷文子、影山晴秋、柴加奈子、塩田清二
  • Organizer: 第64回日本体力医学会大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-18
• [Presentation] Feeding regulation and energy metabolism in brain-Novel GPCR ligands- (2009)
  • Author(s): Shioda S, Takenoya F, Shiba K, Kageyama H
  • Organizer: Malaysian Association for the Study of Obesity(MASO) 2009, Scientific conference on obesity
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2009-08-13
• [Presentation] Feeding regulation in brain-novel GPCR ligands. A joint international Meeting (2009)
  • Author(s): Shioda S, Kageyama H, Takenoya F
  • Organizer: The 5th International Symposium PEPTIDE RECEPTORS & KININ2009, The Inaugural Meeting of the Canadian Branch of the international Neuropeptide Society
  • Place of Presentation: Quebec City, Quebec, Canada
  • Year and Date: 2009-06-26
• [Presentation] Neuronal interaction between neuropeptide W(NPW)-and other feeding regulatory peptides in rat brain. A joint international Meeting (2009)
  • Author(s): Takenoya F, Kageyama H, Date Y, Nakazato M, Shioda S
  • Organizer: The 5th International Symposium PEPTIDE RECEPTORS & KININ2009, The Inaugural Meeting of the Canadian Branch of the international Neuropeptide Society
  • Place of Presentation: Quebec City, Quebec, Canada
  • Year and Date: 2009-06-26
• [Presentation] Effects of galanin-like peptide(GALP) on the autonomic nervous system in the rat. A joint international Meeting (2009)
  • Author(s): Kageyama H, Niijima A, Takenoya F, Shioda S
  • Organizer: The 5th International Symposium PEPTIDE RECEPTORS & KININ2009, The Inaugural Meeting of the Canadian Branch of the international Neuropeptide Society
  • Place of Presentation: Quebec City, Quebec, Canada
  • Year and Date: 2009-06-26
• [Book] 神経ペプチドによる食欲・エネルギー代謝調節 (2010)
  • Author(s): 塩田清二、竹ノ谷文子、柴加奈子、影山晴秋
  • Total Pages: 85-92
  • Publisher: 顎機能誌
• [Book] Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding (2010)
  • Author(s): Kageyama H, Takenoya F, Shiba K, Shioda S
  • Total Pages: 133-138
  • Publisher: Neuropeptides
• [Book] Neuropeptide W : a key player in the homeostatic regulation of feeding and energy metabolism (2010)
  • Author(s): Takenoya F, Kageyama H, Shiba K, Date Y, Nakazato M, Shioda S
  • Total Pages: 162-169
• [Book] Galanin-like peptide and the regulation of feeding behavior and energy metabolism (2010)
  • Author(s): Shiba K, Kageyama H, Takenoya F, Shioda S
  • Total Pages: 5006-5013
  • Publisher: FEBS J
• [Book] Feeding regulation in the brain : Involvement of Neuropeptide W. Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience- (2009)
  • Author(s): Takenoya F, Kageyama H, Date Y, Nakazato M, Shioda S
  • Total Pages: 31-39
  • Publisher: Springer(Tokyo)
• [Book] Feeding regulation in the brain : role of Galanin-like peptide(GALP). Transmitters and Modulators in Health and Disease-New Frontiers in Neuroscience- (2009)
  • Author(s): Kageyama H, Takenoya F, Shioda S
  • Total Pages: 41-48
  • Publisher: Springer(Tokyo)