2011 Fiscal Year Final Research Report
Identification of the host factors involved in the response of macrophage cells to Legionella pneumophila infection
| Project/Area Number |
21659108
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | 細胞死 / マクロファージ / レジオネラ / カスパーゼ |
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| Research Abstract |
To investigate the role of Naip5 in macrophage survival, RAW264 macrophages expressing Naip5 were constructed. Naip5 promoted cytotoxicity in Legionella pneumophila-infected cells. This cytotoxicity was associated with caspase-1. In addition, Naip5 restricted the intracellular growth of L. pneumophila in RAW264 cells. L. pneumophila flagellin was required for cytotoxicity, caspase-1 activation, and restriction of intracellular bacterial growth. Moreover, Naip5 inhibited camptothecin-induced apoptosis in macrophages. These data indicate that Naip5 regulate cell survival by inhibiting apoptosis or by promoting pyroptosis in response to specific cellular signals.
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[Journal Article] Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections2010
Author(s)
Akiyama T, Miyamoto H, Fukuda K, Sano N, Katagiri N, Shobuike T, Kukita A, Yamashita Y, Taniguchi H, Goto M.
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Journal Title
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
Volume: 109(5)
Pages: 669-676
Peer Reviewed
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