Construction of the experimental system about the immunity influence of an indoor disposition

2011 Fiscal Year Final Research Report

• Project/Area Number: 21659161
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Kawasaki Medical School
• Principal Investigator: OTSUKI Takemi 川崎医科大学, 医学部, 教授 (40160551)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA Yasumitsu 川崎医科大学, 医学部, 准教授 (90360271) ; TAKEI Naoko 川崎医科大学, 医学部, 助教 (00509276) ; MATSUZAKI Hidenori 川崎医科大学, 医学部, 助教 (80335463) ; LEE Suni 川崎医科大学, 医学部, 助教 (70414026) ; MAEDA Megumi 川崎医科大学, 医学部, 助教 (20434988)
• Project Period (FY): 2009 – 2011
• Keywords: マイナス荷電粒子 / 室内気質 / 免疫 / T細胞 / NK細胞 / 活性化 / サイトカイン

Research Abstract

Result to build a negatively charged particle indoor air quality advantage, stay for 2.5 hours by healthy volunteers, have been type tested and only at night for two weeks, and minor but significant increase in interleukin-2 short-term, so had observed enhanced activity of natural killer cells in the(2 weeks) period during this time, and the experimental building of that system, the result was verified, the degree of dominance of the charged particle is negative, the order experimentally were different, experimentally, it was found that this environment to induce the activation of natural killer cell helper T cell activation.

Research Products

• [Journal Article] 森林環境要素の免疫機能に及ぼす効果 (2011)
  • Author(s): 大槻剛巳
  • Journal Title: 森林セラピー Volume: Np. 5 Pages: 6
• [Journal Article] Two weeks of permanence in negatively-charged air conditions causes alteration of natural killer cell function (2009)
  • Author(s): Takahashi K, Otsuki T, Mase A, Kawado T, Kotani M, Nishimura Y, Maeda M, Murakami S, Kumagai N, Hayashi H, Chen Y, Shirahama T, Miura Y, Morimoto K.
  • Journal Title: Int J Immunopathol Pharmacol Volume: 22(2) Pages: 333-342
  • Peer Reviewed
• [Journal Article] The biological effects of negatively-charged indoor aire conditions (2009)
  • Author(s): Otsuki T, Takahashi K, Mase A, Kawado T, Kotani M, Maeda M, Murakami S, Kumagai N, Hayashi H, Chen Y, Nishimura Y, Miura Y, Shirahama T, Yoshimatsu M, Morimoto K.
  • Journal Title: Kawasaki Med J Volume: 35(3) Pages: 205-214
  • Peer Reviewed
• [Journal Article] マイナス荷電粒子優位な室内空気環境の生体影響の観察-精神・神経・内分泌・免疫ネットワークへの影響について- (2009)
  • Author(s): 西村泰光, 高橋一聡, 間瀬昭則, 河戸隆, 小谷宗男, 阿見和久, 松島弘樹, 白濱毅, 吉松道晴, 前田恵, 村上周子, 林宏明, 熊谷直子, 陳〓, 三浦由恵, 森本兼曩, 大槻剛巳
  • Journal Title: 日本職業・環境アレルギー学会雑誌 Volume: 16(2) Pages: 15-24
  • Peer Reviewed
• [Presentation] 室内空気質による健康増進への取組に関する基礎的研究 (2011)
  • Author(s): 大槻剛巳
  • Organizer: 第2回川崎医科大学学術集会
  • Place of Presentation: 川崎医科大学現代医学教育博物館
  • Year and Date: 2011-08-06
• [Presentation] 健康増進住宅への試み (2011)
  • Author(s): 大槻剛巳
  • Organizer: 第39回メディカルテクノおかやまサロン
  • Place of Presentation: 岡山大学鹿田キャンパス総合教育研究棟1階
  • Year and Date: 2011-04-25
• [Presentation] マイナス荷電粒子優位の室内空気環境と精神・神経・内分泌・免疫ネットワーク応答の解析-in vitro実験系の試み- (2010)
  • Author(s): 大槻剛巳, 西村泰光, 前田恵, 熊谷直子, 林宏明
  • Organizer: 第1回川崎医科大学学術集会
  • Place of Presentation: 川崎医科大学校舎棟M702/教職員ラウンジ
  • Year and Date: 2010-08-07
• [Presentation] 環境と生体反応:健康被害から健康増進へ (2009)
  • Author(s): 大槻剛巳
  • Organizer: 岡山県医用工学研究会平成21年度第1回セミナー
  • Place of Presentation: 岡山大学鹿田キャンパス附属図書館3階情報実習室
  • Year and Date: 2009-06-18
• [Presentation] マイナス荷電空気環境による効果 (2009)
  • Author(s): 大槻剛巳, 西村泰光, 森本兼曩
  • Organizer: 第79回日本衛生学会総会「森林の健康影響メカニズムをさぐる」森林医学研究会
  • Place of Presentation: 北里大学白金キャンパス
  • Year and Date: 2009-03-30
• [Book] Establishment of Negatively-charged Indoor Air Conditions and their Biological Effects. In Buildings and the Environment. Authors/Editors : Jonas Nemecek and Patrik Schulz (2009)
  • Author(s): Otsuki T, Takahashi K, Mase A, Kawado T, Kotani M, Nishimura Y, Maeda M, Murakami S, Kumagai N, Hayashi H, Chen Y, Miura Y, Shirahama T, Yoshimatsu M, Morimoto K.
  • Total Pages: 201-214
  • Publisher: Nova Science Publishers