2011 Fiscal Year Final Research Report
Study on effective treatment of infective endocarditis using sonoporation and nano-size bubble liposome
| Project/Area Number |
21659201
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MARUYAMA Kazuo 帝京大学, 薬学部, 教授 (30130040)
ASANUMA Toshihiko 大阪大学, 大学院・医学系研究科, 寄附講座准教授 (80379271)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 臨床心血管病態学 / 超音波治療 |
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| Research Abstract |
Vegetation seen in infective endocarditis is covered by the biofilm which prevents effective penetration of antibiotics. We evaluated the feasibility of sonoporation as an aid of drug delivery to vegetation. We found combination of nano-size bubble liposomes and ultrasound exposure enhanced the ability of dye penetration to vegetation obtained from rat endocarditis model.
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