2011 Fiscal Year Final Research Report
The lighting effects on development of endometrial hyperplasia
| Project/Area Number |
21659260
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
OKAMURA Kunihiro 東北大学, 大学院・医学系研究科, 名誉教授 (90124560)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Hidenobu 東北大学, 大学院・医学系研究科, 非常勤 (80422103)
CHISAKA Hiroshi 東北大学, 大学院・医学系研究科, 非常勤講師 (40323026)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 子宮内膜症 / 光環境 / エストロゲン |
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| Research Abstract |
This research aims to clarify how illumination during night leads to endometrial hyperplasia using the estrogen signal pathway of an animal model. We evaluated the effects of night illumination on transplanted endometrial tissues using a Bmal1-reporter system and also examined the degree of hyperplasia by measuring the growth sizes of endometrial tissues and serum estrogen levels (E1, E2).
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