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2011 Fiscal Year Final Research Report

Development of in vivo imaging probes for measurement of cell mass in pancreatic islets.

Research Project

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Project/Area Number 21659289
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

SAJI Hideo  京都大学, 大学院・薬学研究科, 教授 (40115853)

Co-Investigator(Kenkyū-buntansha) TEMMA Takashi  京都大学, 大学院・薬学研究科, 助教 (90378787)
TOYODA Kentaro  京都大学, 大学院・医学研究科, 助教 (00447971)
Co-Investigator(Renkei-kenkyūsha) KIMURA Hiroyuki  京都大学, 環境安全保健機構・放射性同位元素総合センター, 助教 (50437240)
Project Period (FY) 2009 – 2011
Keywords糖尿病 / 早期診断 / 分子イメージング / 画像診断
Research Abstract

If a decrease in the amount of pancreatic islets and the amount of pancreatic.-cells can be detected at an early stage, there is a possibility for the prevention and treatment of diabetes. Therefore, a noninvasive technique for imaging of pancreatic islets, particularly a noninvasive technique for imaging of pancreatic islets for determining the amount of the pancreatic islets and the amount of pancreatic.-cells, has been desired for the prevention and diagnosis of diabetes. Among these, a molecular probe that enables the imaging of pancreatic islets, preferably the pancreatic.-cell imaging, has been desired in particular. In designing a molecular probe for imaging of pancreatic.-cells, various targets molecule in pancreatic islet cells, particularly functional proteins specific in the.-cells, are being researched. Among these, GLP-1R and GPR40 are being researched as a target molecule. These data suggest that[111In] K4-Ex4 and[125I] ARKM-405 can be a potential candidate as a SPECT tracer for measuringβ-cell mass in pancreatic islets.

  • Research Products

    (14 results)

All 2012 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Microwave-assisted Synthesis of Organometallic Complexes of 99mTc(CO) 3and Re(CO) 3 : Its Application to Radiopharmaceuticals2012

    • Author(s)
      Kimura H, Mori D, Harada N, Ono M, Ohmomo Y, Kajimoto T, Kawashima H, Saji H.
    • Journal Title

      Chemical & Pharmaceutical Bulletin

      Volume: 60(1) Pages: 79-85

    • URL

      http://dx.doi.org/10.1248/cpb.60.79

    • Peer Reviewed
  • [Journal Article] Effective Synthesis of 99mTc Tricarbonyl Complexes by Microwave Heating2011

    • Author(s)
      Harada N, Kimura H, Ono M, Mori D, Ohmomo Y, Kajimoto T, Kawashima H, Saji H.
    • Journal Title

      Journal of Organometallic Chemistry

      Volume: 696 Pages: 3745-3749

    • URL

      http://dx.doi.org/10.1016/j.jorganchem.2011.08.033

    • Peer Reviewed
  • [Journal Article] GLP-1receptor antagonist as a potential probe for pancreatic beta-cell imaging2009

    • Author(s)
      Mukai E, Toyoda K, Kimura H, KawashimaH, Fujimoto H, Ueda M, Temma T, Hirao K, Nagakawa K, Saji H, Inagaki N.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 389 Pages: 523-6

    • URL

      http://dx.doi.org/10.1016/j.bbrc.2009.09.014

    • Peer Reviewed
  • [Presentation] Development of the Imaging Probe Targeting Pancreatic GLP-1Receptors for Noninvasive Detection of Pancreaticυ-cell Mass2011

    • Author(s)
      Ogawa Y, Kimura H, Kawashima H, Toyoda K, Mukai E, Fujimoto H, Hirao K, Ono M, Inagaki N, Saji H.
    • Organizer
      The 8th AFMC International Medicinal Chemistry Symposium(AIMECS 11)
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      20111129-1202
  • [Presentation] 膵β細胞GLP-1受容体を標的とするSPECT用イメージングプローブExendin(9-39)誘導体の開発2011

    • Author(s)
      小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
    • Organizer
      第51回日本核医学会学術総会
    • Place of Presentation
      つくば国際会議場(茨城)
    • Year and Date
      2011-10-28
  • [Presentation] 膵β細胞GLP-1受容体標的放射性プローブとしてのI-123標識Exendin-4誘導体2011

    • Author(s)
      小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
    • Organizer
      第9回次世代を担う若手のためのフィジカル・ファーマコフォーラム(PPF2011)
    • Place of Presentation
      ホテル箱根アカデミー(神奈川県)
    • Year and Date
      2011-09-12
  • [Presentation] Radiosynthesis and evaluation of F-18 Exendin-4 derivatives as a PET tracer for the imaging of GLP-1receptors on pancreaticβ-cells2011

    • Author(s)
      Kimura H, Ogawa Y, Kawashima H, Toyoda K, Mukai E, Fujimoto H, Ono M, Hirao K, Inagaki N, Saji H.
    • Organizer
      Society of Nuclear Medicine 58th Annual Meeting
    • Place of Presentation
      San Antonio, Texas(USA)
    • Year and Date
      2011-06-06
  • [Presentation] Development of 123Ilabeled Exendin derivatives for the imaging of GLP-1 receptors on pancreaticβ-cellwith SPECT2011

    • Author(s)
      Ogawa Y, Kimura H, Kawashima H, Toyoda K, Mukai E, Fujimoto H, Hirao K, Ono M, Inagaki N, Saji H.
    • Organizer
      Society of Nuclear Medicine 58th Annual Meeting
    • Place of Presentation
      San Antonio, Texas(USA)
    • Year and Date
      2011-06-06
  • [Presentation] 膵β細胞GLP-1受容体を標的とするSPECT用イメージングプローブの開発2011

    • Author(s)
      小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      ツインメッセ静岡(静岡県)
    • Year and Date
      2011-03-30
  • [Presentation] GLP-1受容体を標的とする放射性ヨウ素標識イメージングプローブの開発2010

    • Author(s)
      小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 松田洋和, 小野正博, 稲垣暢也, 佐治英郎
    • Organizer
      第50回日本核医学会学術総会
    • Place of Presentation
      ソニックシティ(埼玉県)
    • Year and Date
      20101111-13
  • [Presentation] GLP-1受容体を標的とする膵β細胞イメージング用放射性プローブの開発2009

    • Author(s)
      小川祐, 木村寛之, 河嶋秀和, 豊田健太郎, 向英里, 藤本裕之, 平尾佳, 永川健児, 小野正博, 稲垣暢也, 佐治英郎
    • Organizer
      第49回日本核医学会学術総会
    • Place of Presentation
      旭川市民文化会館(北海道)
    • Year and Date
      2009-10-02
  • [Presentation] Development of in vivo imaging agents targeting glucagon-like peptide-1receptor(GLP-1R) in pancreatic islets2009

    • Author(s)
      Kimura H, Ogawa Y, Kawashima H, Mukai E, Toyoda K, Fujimoto H, Hirao K, Nagakawa K, Ono M, Inagaki N, Saji H.
    • Organizer
      World Molecular Imaging Congress 2009
    • Place of Presentation
      Montreal(Canada)
    • Year and Date
      2009-09-25
  • [Presentation] Development of in vivo imaging agents targeting glucagon-like peptide-1receptor(GLP-1R) in pancreatic islets2009

    • Author(s)
      Kimura H, Ogawa Y, Kawashima H, Mukai E, Toyoda K, Fujimoto H, Hirao K, Nagakawa K, Ono M, Inagaki N, Saji H.
    • Organizer
      Society of Nuclear Medicine 56th Annual Meeting
    • Place of Presentation
      Toronto(Canada)
    • Year and Date
      2009-06-13
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/byotai/

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Published: 2013-07-31  

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