2011 Fiscal Year Final Research Report
What is the role of glomeruloid vessels in glioblastoma?
| Project/Area Number |
21659338
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
TAKANO Shingo 筑波大学, 医学医療系, 准教授 (50292553)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAI Yasunobu 筑波大学, 医学医療系, 講師 (40535069)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 膠芽腫 / 血管新生 / 腫瘍内皮細胞 / ケモカイン / 抵抗性 / 腫瘍微小環境 |
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| Research Abstract |
Glomeruloid vessel (GV) is a hallmark of glioblastoma vasculature. The role of GV was investigated with genetic alteration and immunohistochemistry using human glioblastoma frozen section. Endoglin, that is related to endothelial cell migration, was up-regulated in GV compared to small tumor vessels and tumor cells. Endoglin was localized in endothelial cells with smooth muscle cell actin and co-localized with phospholylated VEGFR2 (marker of VEGF antibody action) and CD133 (stem cell marker). Targeting endoglin has a possibility of a effective anti-angiogenic therapy damaging endothelial stem cell in glioblastoma.
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[Journal Article] Immunohistochemical detection of IDH1 mutation, p53 and internexin as a prognostic marker ofglial tumors2012
Author(s)
Takano S, Kato Y, Yamamoto T, Kaneko MK, Ishikawa E, Tsujimoto Y, Matsuda M, Nakai K, Yanagiya R, Morita S, Tsuboi K, Matsumura A
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Journal Title
DOI
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[Journal Article] Pathological changes after autologous formalin-fixed tumorvaccine therapy combined with temozolomide for glioblastoma. three case reports-2011
Author(s)
Sakamoto N, Ishikawa E, Yamamoto T, Satomi K, Nakai K, Sato M, EnomotoT, Morishita Y, Takano S, Ohno T, Tsuboi K, Matsumura A
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Journal Title
Neurol Med Chir (Tokyo)
Pages: 319-325
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