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2011 Fiscal Year Final Research Report

Elucidating the bone resorption mechanism using a glycobiological approach

Research Project

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Project/Area Number 21659346
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHokkaido University

Principal Investigator

IWASAKI Norimasa  北海道大学, 大学院・医学研究科, 准教授 (30322803)

Co-Investigator(Kenkyū-buntansha) ABE Yuichirou  北海道大学, 北海道大学病院, 助教 (80547604)
Project Period (FY) 2009 – 2011
Keywords骨吸収 / 破骨細胞 / 糖鎖 / ガングリオシド / 脂質ラフト
Research Abstract

We established expression profiles of N-linked glycans and glycosphingolipids during osteoclastogenesis. Among glycosphingolipids expressed on osteoclasts and these precursor cells, we identified GD1/ganglioside as a negative regulator of proliferation of osteoclast precursor cells.

  • Research Products

    (2 results)

All 2012 Other

All Presentation (2 results)

  • [Presentation] A Member of Sialic Acid-Binding Immunoglobulin-Like lectin 15(Siglec-15) Associates with DAP12-mediated Costimulatory Signal in Osteoclastogenesis2012

    • Author(s)
      Miki Komatsu, Masahiko Takahata, Norimasa Iwasaki.
    • Organizer
      The orthopaedic Research Society(ORS) annual meeting 2012
    • Place of Presentation
      米国: Moscone West Convention Center
    • Year and Date
      20120000
  • [Presentation] 免疫グロブリン様レクチンSiglec-15はDAP12を介した共刺激シグナルに関与し破骨細胞分化を制御する

    • Author(s)
      小松幹,高畑雅彦,岩崎倫政
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪市:大阪国際会議場

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Published: 2013-07-31  

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