2011 Fiscal Year Final Research Report
Induction of the tumor immune response by the dendritic cell targeting of the autoantigen mimotope.
| Project/Area Number |
21659374
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
HANAFUSA Tadashi 岡山大学, 自然生命科学研究支援センター, 助教 (00228511)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 腫瘍学 / ミモトープ |
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| Research Abstract |
In this study, I tried to identify the CD8 T-cell epitopes and its mimotopes of PCDH11Y that is expressed on prostate cancer cells, and tried to induce tumor specific immune response by dendritic cell targeting of its sequence. I didn' t succeed the isolation of epitopes, but I succeeded the construction of scFv antibody that recognizes the extracellular domain of PCHD11Y, and its humanization. I postulated that the induction of tumor specific immune response could be induced using this antibody by the ADCC mechanism.
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