2011 Fiscal Year Final Research Report
Induction of the tumor immune response by the dendritic cell targeting of the autoantigen mimotope.
| Project/Area Number |
21659374
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
HANAFUSA Tadashi 岡山大学, 自然生命科学研究支援センター, 助教 (00228511)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Keywords | 腫瘍学 / ミモトープ |
|---|
| Research Abstract |
In this study, I tried to identify the CD8 T-cell epitopes and its mimotopes of PCDH11Y that is expressed on prostate cancer cells, and tried to induce tumor specific immune response by dendritic cell targeting of its sequence. I didn' t succeed the isolation of epitopes, but I succeeded the construction of scFv antibody that recognizes the extracellular domain of PCHD11Y, and its humanization. I postulated that the induction of tumor specific immune response could be induced using this antibody by the ADCC mechanism.
|
Research Products
(5 results)
