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2011 Fiscal Year Final Research Report

Autologous transplantation of conjunctival epithelial stem cells

Research Project

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Project/Area Number 21659398
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionThe University of Tokyo (2011)
Okinaka Memorial Institute for Medical Research (2009-2010)

Principal Investigator

MIMURA Tatsuya  東京大学, 医学部附属病院, 助教 (70463867)

Project Period (FY) 2009 – 2011
Keywords前駆細胞 / 幹細胞 / 角膜 / 結膜
Research Abstract

We cultured corneal and conjunctival epithelial cells from donor eye and rabbit eye. Additionally, we developed an adult precursor/stem cell isolation method(the sphere-forming assay) for corneal and conjunctival epithelial cells. We demonstrated corneal and conjunctival precursor/stem cells possessed the higher proliferative capacity as indicated by BrDU staining and the immature state as indicated by nestin staining compared with cultured differentiated epithelial cells. We cultured conjunctival epithelial cells on the denuded amniotic membrane and demonstrated that cultured conjuncdtival epithelium formed three to four layers on amniotic membrane. After transplantation of cultured conjunctival epithelial sheet on the rabbit cornea with corneal epithelial opacity and conjunctival invasion onto cornea, transplanted rabbit cornea maintained corneal clarity. These results suggest that transplantation of reconstructed conjunctival epithelial sheet using cultured conjunctival epithelial cells to the cornea is a possible treatment strategy for treating total limbal stem cell deficiency.

  • Research Products

    (116 results)

All 2012 2011 2010 2009 Other

All Journal Article (79 results) (of which Peer Reviewed: 79 results) Presentation (36 results) Book (1 results)

  • [Journal Article] Functional-morphological changes afterintravitreal injection of triamcinolone acetonidefor macular edema with branch retinal veinocclusion2012

    • Author(s)
      Noma H, Funatsu H, Mimura T, Shimada K
    • Journal Title

      J Ocul Pharmacol Ther

    • DOI

      DOI:10.1089/jop.2011.0137

    • Peer Reviewed
  • [Journal Article] Vascular endothelial growth factor receptor-2 inmacular oedema with retinal veinocclusion2012

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S
    • Journal Title

      Ophthalmic Res

      Volume: 48(1) Pages: 56-58

    • DOI

      DOI:10.1159/000336020

    • Peer Reviewed
  • [Journal Article] Inflammatory factors in major andmacular branch retinal vein occlusion2012

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K.
    • Journal Title

      Ophthalmologica

      Volume: 227(3) Pages: 146-52

    • DOI

      DOI:10.1159/000335047

    • Peer Reviewed
  • [Journal Article] Vitreous InflammatoryFactors and Serous Macular Detachment inBranch Retinal Vein Occlusion2012

    • Author(s)
      Noma H, Funatsu H, Mimura T, Tatsugawa M, Shimada K, Eguchi S
    • Journal Title

      Retina

      Volume: 32(1) Pages: 86-91

    • URL

      http://www.journal-inflammation.com/content/8/1/38

    • Peer Reviewed
  • [Journal Article] Vascularendothelial growth factor and Interleukin-6 arecorrelated with serous retinal detachment incentral retinal vein occlusion2012

    • Author(s)
      Noma H, Funatsu H, Mimura T
    • Journal Title

      Curr Eye Res

      Volume: 37(1) Pages: 62-7

    • DOI

      DOI:10.3109/02713683.2011.614370

    • Peer Reviewed
  • [Journal Article] Pinguecula and diabetes mellitus2012

    • Author(s)
      Mimura T, Obata H, Usui T, Mori M, Yamagami S, Funatsu H, Noma H, Amano S
    • Journal Title

      Cornea

      Volume: 31(3) Pages: 264-8

    • DOI

      DOI:10.1097/ICO.0b013e3182254170

    • Peer Reviewed
  • [Journal Article] Vitreous inflammatory factors and macularoedema2012

    • Author(s)
      Funatsu H, Noma H, Mimura T, Eguchi S
    • Journal Title

      Br J Ophthalmol

      Volume: 96(2) Pages: 302-4

    • DOI

      DOI:10.1136/bjo.2010.181222

    • Peer Reviewed
  • [Journal Article] Vitreous inflammatory factors and serous retinaldetachment in central retinal vein occlusion : acase control series2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S
    • Journal Title

      J Inflamm(Lond)

      Volume: 8(1) Pages: 38

    • DOI

      DOI:10.1159/000335047

    • Peer Reviewed
  • [Journal Article] Prospects for Descemet strippingautomated endothelial keratoplasty using culturedhuman corneal endothelial cells2011

    • Author(s)
      Mimura T, Yamagami S, Yokoo S, Usui T, Amano S
    • Journal Title

      J Transplant Technol Res

      Pages: S2-001

    • URL

      http://dx.doi.org/10.4172/2161-0991.S2-001

    • Peer Reviewed
  • [Journal Article] Influence of vitreous factors aftervitrectomy for macular edema in patients withcentral retinal vein occlusion2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K
    • Journal Title

      Int Ophthalmol

      Volume: 31(5) Pages: 393-402

    • DOI

      DOI:10.1007/s10792-011-9480-6

    • Peer Reviewed
  • [Journal Article] Recentadvances and history of vitreous surgery2011

    • Author(s)
      Mimura T, Nakashizuka T, Mori M
    • Journal Title

      Journalof Healthcare Engineering

      Volume: 2(4) Pages: 447-458

    • DOI

      DOI:10.1260/2040-2295.2.4.447

    • Peer Reviewed
  • [Journal Article] Visual function and serous retinal detachment inpatients with branch retinal vein occlusion andmacular edema : a case series2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Shimada K
    • Journal Title

      BMC Ophthalmol

      Volume: 11(1) Pages: 29

    • URL

      http://www.biomedcentral.com/1471-2415/11/29

    • Peer Reviewed
  • [Journal Article] Influence of ischemia for visual function inpatients with branch retinal vein occlusion andmacular edema2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Shimada K
    • Journal Title

      Clinical Ophthalmology

      Volume: 5 Pages: 679-685

    • DOI

      DOI:10.2147/OPTH.S20527

    • Peer Reviewed
  • [Journal Article] Asymptomaticsubconjunctival entrapment of a cilium2011

    • Author(s)
      Mimura T, Nakashizuka T, Kami J, Kohmura M, Sato S, Dou K, Mori M
    • Journal Title

      IntOphthalmol

      Volume: 31(4) Pages: 325-6

    • DOI

      DOI:10.1007/s10792-011-9449-5

    • Peer Reviewed
  • [Journal Article] Soluble vascular endothelial growthfactor receptor-2 and inflammatory factors inmacular edema with branch retinal vein occlusion2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguch S, Hori S
    • Journal Title

      Am J Ophthalmol

      Volume: 152(4) Pages: 669-677

    • DOI

      DOI:10.1016/j.ajo.2011.04.006

    • Peer Reviewed
  • [Journal Article] Effect of trabeculectomy onocular and corneal higher order aberrations2011

    • Author(s)
      Fukuoka S, Amano S, Honda N, Mimura T, Usui T, Araie M
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55(5) Pages: 460-6

    • DOI

      DOI:10.1007/s10384-011-0063-x

    • Peer Reviewed
  • [Journal Article] Conjunctivochalasis : associations withpinguecula in a hospital-based study2011

    • Author(s)
      Mimura T, Mori M, Obata H, Usui T, Yamagami S, Funatsu H, Noma H, Amano S
    • Journal Title

      Acta Ophthalmol

    • DOI

      DOI:10.1111/j.1755-3768.2011.02161.x

    • Peer Reviewed
  • [Journal Article] Functional-morphological correlatesin patients with branch retinal vein occlusion andmacular edema2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Harino S, Shimada K
    • Journal Title

      Retina

      Volume: 31(10) Pages: 2102-8

    • DOI

      DOI:10.1097/IAE.0b013e318212e24d

    • Peer Reviewed
  • [Journal Article] Specific tear IgE in patients withmoderate-to-severe autumnal allergicconjunctivitis2011

    • Author(s)
      Mimura T, Usui T, Mori M, Funatsu H, Noma H, Amano S
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 156(4) Pages: 381-386

    • DOI

      DOI:10.1159/000323908

    • Peer Reviewed
  • [Journal Article] Role ofMT1-MMP on anti-angiogenic proteoglycan, Decorin, in corneal angiogenesis2011

    • Author(s)
      Mimura T, Chang JH, Kim TI, Onguchi T, Kojima T, Sakimoto T, Azar DT
    • Journal Title

      Cornea

      Pages: 45-9

    • DOI

      DOI:10.1097/ICO.0b013e31822816e0

    • Peer Reviewed
  • [Journal Article] Relationship between conjunctivochalasis andrefractive error2011

    • Author(s)
      Mimura T, Usui T, Yamagami S, Funatsu H, Noma H, Toyono T, Mori M, Amano S
    • Journal Title

      Eye Contact Lens

      Volume: 37(2) Pages: 71-8

    • DOI

      DOI:10.1097/ICL.0b013e31820ca377

    • Peer Reviewed
  • [Journal Article] Visual prognosis and vitreousmolecules after vitrectomy for macular edemawith branch retinal vein occlusion2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K
    • Journal Title

      Clin Ophthalmol

      Volume: 5 Pages: 223-9

    • DOI

      DOI:10.2147/OPTH.S16552

    • Peer Reviewed
  • [Journal Article] Relation between total tear IgE and specificserum IgE in seasonal allergic conjunctivitis2011

    • Author(s)
      Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, Aixinjueluo W, Amano S
    • Journal Title

      Cornea

      Volume: 30(7) Pages: 790-5

    • DOI

      DOI:10.1097/ICO.0b013e3182000feb

    • Peer Reviewed
  • [Journal Article] Sudden onset of amantadineinduced reversible bilateral corneal edema in anelderly patient : Case report and literature review2011

    • Author(s)
      Hotehama A, Mimura T, Usui T, Kawashima H, Amano S
    • Journal Title

      Sudden onset of amantadineinduced reversible bilateral corneal edema in anelderly patient : Case report and literature review

      Volume: 55(1) Pages: 71-74

    • DOI

      DOI:10.1007/s10384-010-0888-8

    • Peer Reviewed
  • [Journal Article] Severity and determinants of pinguecula in ahospital-based population2011

    • Author(s)
      Mimura T, Usui T, Obata H, Yamagami S, Mori M, Funatsu H, Noma H, Dou K, Amano S
    • Journal Title

      Eye Contact Lens

      Volume: 37(1) Pages: 31-35

    • DOI

      DOI:10.1097/ICL.0b013e3181bece3d

    • Peer Reviewed
  • [Journal Article] Vitreous levels of pigmentepithelium-derived factor and vascularendothelial growth factor in macular edema withcentral retinal vein occlusion2011

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K, Hori S
    • Journal Title

      Curr Eye Res

      Volume: 36(3) Pages: 256-63

    • DOI

      DOI:10.3109/02713683.2010.513090

    • Peer Reviewed
  • [Journal Article] Rapid immunochromatographicmeasurement of specific tear IgE in moderate tosevere cases of allergic conjunctivitis withimmfast check J1 in the spring2011

    • Author(s)
      Mimura T, Usui T, Mori M, Funatsu H, Noma H, Amano S
    • Journal Title

      Cornea

      Volume: 30(5) Pages: 524-7

    • DOI

      DOI:10.1097/ICO.0b013e3181f23932

    • Peer Reviewed
  • [Journal Article] Relationship between total tear and serum IgE inallergic conjunctivitis2011

    • Author(s)
      Mimura T, Usui T, Mori M, Funatsu H, Noma H, Yamamoto H, Aixinjueluo W, Amano S
    • Journal Title

      Int Arch Allergy Immunol

      Volume: 154(4) Pages: 349-52

    • DOI

      DOI:10.1159/000321828

    • Peer Reviewed
  • [Journal Article] Lasertreatment of giant iris cyst withnanophthalmos2011

    • Author(s)
      Honda N, Mimura T, Hotehama A, Usui T, Sugisaki K, Fukuoka S, Amano S
    • Journal Title

      Int Ophthalmol

      Volume: 31(1) Pages: 17-20

    • DOI

      DOI:10.1007/s10792-010-9385-9

    • Peer Reviewed
  • [Journal Article] Vitreous inflammatory factorsin macular edema with central retinal veinocclusion2010

    • Author(s)
      Noma H, Funatsu H, Harino S, Mimura T, Eguchi S, Hori S
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54(5) Pages: 430-4

    • DOI

      DOI:10.1007/s10384-011-0016-4

    • Peer Reviewed
  • [Journal Article] High-dose steroid therapy for idiopathic opticperineuritis : a case series2010

    • Author(s)
      Tatsugawa M, Noma H, Mimura T, Funatsu H
    • Journal Title

      J Med Case Reports

      Volume: 4(1) Pages: 404

    • DOI

      DOI:10.1186/1752-1947-3-104

    • Peer Reviewed
  • [Journal Article] Immunochromatographic assay for measurementof total IgE in tears, nasal mucus, and saliva ofpatients with allergic rhinoconjunctivitis2010

    • Author(s)
      Mimura T, Usui T, Mori M, Aixinjueluo W, Funatsu H, Noma H, Amano S
    • Journal Title

      J Asthma

      Volume: 47(10) Pages: 1153-60

    • DOI

      DOI:10.3109/02770903.2010.527025

    • Peer Reviewed
  • [Journal Article] Increase of aqueous inflammatory factors inmacular edema with branch retinal veinocclusion : a case control study2010

    • Author(s)
      Noma H, Funatsu H, Mimura T, Shimada K
    • Journal Title

      J Inflamm(Lond)

      Volume: 7(1) Pages: 44

    • DOI

      DOI:10.1186/1476-9255-8-38

    • Peer Reviewed
  • [Journal Article] Pigment epithelium-derivedfactor and vascular endothelial growth factor inbranch retinal vein occlusion with macular edema2010

    • Author(s)
      Noma H, Funatsu H, Mimura T, Harino S, Eguchi S, Hori S
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 248(11) Pages: 1559-65

    • DOI

      DOI:10.1007/s00417-010-1486-7

    • Peer Reviewed
  • [Journal Article] Bilateral limbal stem celldeficiency with chromosomal translocation of 3pand 9p2010

    • Author(s)
      Usui T, Nakagawa S, Yokoo S, Mimura T, Y amagami S, Amano S
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54(4) Pages: 357-8

    • DOI

      DOI:10.1007/s10384-010-0814-0

    • Peer Reviewed
  • [Journal Article] Isolation of adultprogenitor cells with neuronal potential fromrabbit corneal epithelial cells in serum-andfeeder layer-free culture conditions2010

    • Author(s)
      Mimura T, Yamagami S, Uchida S, Yokoo S, Ono K, Usui T, Amano S
    • Journal Title

      Mol Vis

      Volume: 16 Pages: 1712-9

    • URL

      http://www.molvis.org/molvis/v16/a185

    • Peer Reviewed
  • [Journal Article] Pinguecula and contactlenses2010

    • Author(s)
      Mimura T, Usui T, Mori M, Yamamoto H, Obata H, Yamagami S, Funatsu H, Noma H, Honda N, Amano S
    • Journal Title

      Eye(Lond)

      Volume: 24(11) Pages: 1685-91

    • DOI

      DOI:10.1038/eye.2010.120

    • Peer Reviewed
  • [Journal Article] Rapidimmunochromatography of total tear IgE inallergic conjunctivitis with allerwatch2010

    • Author(s)
      Mimura T, Usui T, Mori M, Funatsu H, NomaH, Aixinjueluo W, Yamamoto H, Amano S
    • Journal Title

      J Investig Allergol Clin Immunol

      Volume: 20(7) Pages: 627-8

    • URL

      http://www.jiaci.org/issues/vol20issue7/14-22.pdf

    • Peer Reviewed
  • [Journal Article] Biology ofcorneal endothelial cells in vivo and in vitro2010

    • Author(s)
      Amano S, Kaji Y, Mimura T
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54(3) Pages: 211-4

    • DOI

      DOI:10.1007/s10384-010-0799-8

    • Peer Reviewed
  • [Journal Article] Conjunctivochalasis and Subconjunctival Hemorrhage2010

    • Author(s)
      Mimura T
    • Journal Title

      Ophthalmology

      Volume: 117(12) Pages: 2444

    • Peer Reviewed
  • [Journal Article] Subconjunctivalhaemorrhage and conjunctivochalasis2010

    • Author(s)
      Mimura T, Amano S
    • Journal Title

      Ophthalmology

      Volume: 117(6) Pages: 1277

    • Peer Reviewed
  • [Journal Article] Contact lens-inducedsubconjunctival hemorrhage2010

    • Author(s)
      Mimura T, Yamagami S, Mori M, Funatsu H, Usui T, Noma H, Amano S
    • Journal Title

      Am J Ophthalmol

      Volume: 150(5) Pages: 656-665

    • DOI

      DOI:10.1016/j.ajo.2010.05.028

    • Peer Reviewed
  • [Journal Article] Blood pressure in subconjunctivalhemorrhage2010

    • Author(s)
      Mimura T
    • Journal Title

      Ophthalmologica

      Volume: 224(5) Pages: 332A

    • DOI

      DOI:10.1159/000313835

    • Peer Reviewed
  • [Journal Article] Influence of macularmicrocirculation and retinal thickness on visualacuity in patients with branch retinal vein occlusion and macular edema2010

    • Author(s)
      Noma H, Funatsu H, Harino S, Nagaoka T, Mimura T, Hori S
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54(5) Pages: 430-4

    • DOI

      DOI:10.1007/s10384-010-0834-9

    • Peer Reviewed
  • [Journal Article] Visual acuity and foveal thicknessafter vitrectomy for macular edema associatedwith branch retinal vein occlusion : a case series2010

    • Author(s)
      Noma H, Funatsu H, Mimura T, Eguchi S, Shimada K
    • Journal Title

      BMC Ophthalmol

      Volume: 10(1) Pages: 11

    • DOI

      DOI:10.1186/1471-2415-10-11

    • Peer Reviewed
  • [Journal Article] Association between macularmicrocirculation and soluble intercellularadhesion molecule-1 in patients with macularedema and retinal vein occlusion2010

    • Author(s)
      Noma H, Funatsu H, Sakata K, Mimura T, Hori S
    • Journal Title

      Graefes ArchClin Exp Ophthalmol

      Volume: 248(10) Pages: 1515-8

    • DOI

      DOI:10.1007/s00417-010-1350-9

    • Peer Reviewed
  • [Journal Article] Corneal EpithelialMT1-MMP Inhibits Vascular Endothelial CellProliferation and Migration2010

    • Author(s)
      Azar DT, Casanova FH, Mimura T, Jain S, Zhou Z, Han KY, Chang JH
    • Journal Title

      Cornea

      Volume: 29(3) Pages: 321-30

    • DOI

      DOI:10.1097/ICO.0b013e3181b1165d

    • Peer Reviewed
  • [Journal Article] Effect of latanoprost on the expression of matrixmetalloproteinases and tissue inhibitor ofmetalloproteinase-1 on the ocular surface2010

    • Author(s)
      Honda N, Miyai T, Nejima R, Miyata K, Mimura T, Usui T, Aihara M, Araie M, Amano S
    • Journal Title

      Arch Ophthalmol

      Volume: 128(4) Pages: 466-71

    • DOI

      DOI:10.1001/archophthalmol.2010.40

    • Peer Reviewed
  • [Journal Article] Selective isolation of young cells fromhuman corneal endothelium by thesphere-forming assay2010

    • Author(s)
      Mimura T, Yamagami S, Yokoo S, Usui T, Amano S
    • Journal Title

      Tissue Eng Part C Methods

      Volume: 16(4) Pages: 803-12

    • DOI

      DOI:10.1089=ten.tec.2009.0608

    • Peer Reviewed
  • [Journal Article] Macular microcirculation before and aftervitrectomy for macular edema with branch retinalvein occlusion2010

    • Author(s)
      Noma H, Funatsu H, Sakata K, Mimura T, Hori S
    • Journal Title

      Graefes Arch Clin ExpOphthalmol

      Volume: 248(3) Pages: 443-5

    • DOI

      DOI:10.1007/s00417-009-1250-z

    • Peer Reviewed
  • [Journal Article] Visual acuity and foveal thickness aftervitrectomy for macular edema2010

    • Author(s)
      Noma H, Funatsu H, Mimura T, Shimada K
    • Journal Title

      Ophthalmologica

      Volume: 224(6) Pages: 367-373

    • DOI

      DOI:10.1159/000313819

    • Peer Reviewed
  • [Journal Article] Extended long-term results ofpenetrating keratoplasty for keratoconus2010

    • Author(s)
      Fukuoka S, Honda N, Ono K, Mimura T, Usui T, Amano S
    • Journal Title

      Cornea

      Volume: 29(5) Pages: 528-30

    • DOI

      DOI:10.1097/ICO.0b013e3181c29705

    • Peer Reviewed
  • [Journal Article] Aqueous humor levels of vasoactivemolecules correlate with vitreous levels andmacular edema in central retinal vein occlusion2010

    • Author(s)
      Noma H, Funatsu H, Mimura T, Harino S, Hori S
    • Journal Title

      Eur J Ophthalmol

      Volume: 20(2) Pages: 402-9

    • URL

      http://www.eur-j-ophthalmol.com

    • Peer Reviewed
  • [Journal Article] Ocular involvement by EBV-positivediffuse large B-cell lymphoma of the elderly, anew disease entity in the WHO classification2010

    • Author(s)
      Tsuji H, Tamura M, Yokoyama M, Takeuchi K, Mimura T
    • Journal Title

      Arch Ophthalmol

      Volume: 128(2) Pages: 258-9

    • DOI

      DOI:10.1001/archophthalmol.2009.381

    • Peer Reviewed
  • [Journal Article] Primary epithelioid haemangioendothelioma ofthe eyelid2010

    • Author(s)
      Tsuji H, Kanda H, Kashiwagi H, Mimura T
    • Journal Title

      Br J Ophthalmol

      Volume: 94(2) Pages: 261-2

    • DOI

      DOI:10.1136/bjo.2008.156497

    • Peer Reviewed
  • [Journal Article] Location and extent of subconjunctivalhemorrhage2010

    • Author(s)
      Mimura T, Yamagami S, Usui T, Funatsu H, Noma H, Honda N, Fukuoka S, Hotta H, Amano S
    • Journal Title

      Ophthalmologica

      Volume: 224(2) Pages: 90-5

    • DOI

      DOI:10.1136/bjo.2008.156497

    • Peer Reviewed
  • [Journal Article] Increase of vascular endothelialgrowth factor and interleukin-6 in the aqueoushumour of patients with macular oedema andcentral retinal vein occlusion2010

    • Author(s)
      Noma H, Funatsu H, Mimura T, Harino S, Sone T, Hori S
    • Journal Title

      Acta Ophthalmol

      Volume: 88(6) Pages: 646-51

    • DOI

      DOI:10.1111/j.1755-3768.2009.01524.x

    • Peer Reviewed
  • [Journal Article] Recent causes ofsubconjunctival hemorrhage2010

    • Author(s)
      Mimura T, Usui T, Yamagami S, Funatsu H, Noma H, Honda N, Amano S
    • Journal Title

      Ophthalmologica

      Volume: 224 Pages: 133-137

    • DOI

      DOI:10.1159/000236038

    • Peer Reviewed
  • [Journal Article] Unusual orbital lymphoma undetectable bymagnetic resonance imaging : a case report2009

    • Author(s)
      Tatsugawa M, Noma H, Mimura T, Funatsu H
    • Journal Title

      J Med Case Reports

      Volume: 3 Pages: 104

    • DOI

      DOI:10.1186/1752-1947-3-104

    • Peer Reviewed
  • [Journal Article] Severe hyperopic shift and irregular astigmatismafter radial keratotomy2009

    • Author(s)
      Mimura T, Fujimura S, Yamagami S, Usui T, Honda N, Shirakawa R, Fukuoka S, Amano S
    • Journal Title

      Eye Contact Lens

      Volume: 35(6) Pages: 345-7

    • DOI

      DOI:10.1097/ICL.0b013e3181bece3d

    • Peer Reviewed
  • [Journal Article] Relationshipbetween myopia and allergen-specific serum IgElevels in patients with allergic conjunctivitis2009

    • Author(s)
      Mimura T, Yamagami S, Usui T, Funatsu H, Noma H, Honda N, Amano S
    • Journal Title

      ClinExperiment Ophthalmol

      Volume: 37(7) Pages: 670-7

    • DOI

      DOI:10.1111/j.1442-9071.2009.02130.x

    • Peer Reviewed
  • [Journal Article] Descemet stripping automated endothelialkeratoplasty using cultured corneal endothelialcells in a rabbit model2009

    • Author(s)
      Honda N, Mimura T, Usui T, Amano S
    • Journal Title

      Arch Ophthalmol

      Volume: 127(10) Pages: 1321-6

    • DOI

      DOI:10.1001/archophthalmol.2009.253

    • Peer Reviewed
  • [Journal Article] Relationship between refractionand allergic conjunctivitis2009

    • Author(s)
      Mimura T
    • Journal Title

      Response to Dantas etal. Eye

      Volume: 24 Pages: 387-388

    • DOI

      DOI:10.1038/eye.2009.92

    • Peer Reviewed
  • [Journal Article] MT1-MMP-mediated cleavage of decorin incorneal angiogenesis2009

    • Author(s)
      Mimura T, Han KY, Onguchi T, Chang JH, Kim TI, Kojima T, Zhou Z, Azar DT
    • Journal Title

      J Vasc Res

      Volume: 46(6) Pages: 541-550

    • DOI

      DOI:10.1159/000226222

    • Peer Reviewed
  • [Journal Article] Subconjunctival hemorrhageand conjunctivochalasis2009

    • Author(s)
      Mimura T, Usui T, Yamagami S, Funatsu H, Noma H, Honda N, Fukuoka S, Shirakawa R, Hotta H, Amano S
    • Journal Title

      Ophthalmology

      Volume: 116(10) Pages: 1880-6

    • DOI

      DOI:10.1016/j.ophtha.2009.03.021

    • Peer Reviewed
  • [Journal Article] Conjunctivochalasis and contact lenses2009

    • Author(s)
      Mimura T, Usui T, Yamamoto H, Yamagami S, Funatsu H, Noma H, Honda N, Fukuoka S, Amano S
    • Journal Title

      Am J Ophthalmol

      Volume: 148(1) Pages: 20-5

    • DOI

      DOI:10.1016/j.ajo.2009.02.018

    • Peer Reviewed
  • [Journal Article] MacularMicrocirculation and Macular Oedema in BranchRetinal Vein Occlusion2009

    • Author(s)
      Noma H, Funatsu H, Sakata K, Harino S, Nagaoka T, Mimura T, Sone T, Hori S
    • Journal Title

      Br J Ophthalmol

      Volume: 93(5) Pages: 630-3

    • DOI

      DOI:10.1136/bjo.2008.146597

    • Peer Reviewed
  • [Journal Article] Primaryorbital lymphomatoid granulomatosis2009

    • Author(s)
      Araki F, Mimura T, Fukuoka S, Tsuji H, Izutsu K, Yamamoto H, Takazawa Y, Kojima T
    • Journal Title

      Br J Ophthalmol

      Volume: 93(4) Pages: 554-6

    • DOI

      DOI:10.1136/bjo.2008.140913

    • Peer Reviewed
  • [Journal Article] Vitreous levels of interleukin-6 andvascular endothelial growth factor in macularedema with central retinal vein occlusion2009

    • Author(s)
      Noma H, Funatsu H, Mimura T, Harino S, Hori S
    • Journal Title

      Ophthalmology

      Volume: 116(1) Pages: 87-93

    • DOI

      DOI:10.1016/j.ophtha.2008.09.034

    • Peer Reviewed
  • [Journal Article] Association of vitreous inflammatoryfactors with diabetic macular edema2009

    • Author(s)
      Funatsu H, Noma H, Mimura T, Eguchi S, Hori S
    • Journal Title

      Ophthalmology

      Volume: 116(1) Pages: 73-9

    • DOI

      DOI:10.1016/j.ophtha.2008.09.037

    • Peer Reviewed
  • [Journal Article] Changes in foveal thickness after vitrectomy formacular edema with branch retinal vein occlusionand intravitreal vascular endothelial growthfactor2009

    • Author(s)
      Yamasaki M, Noma H, Funatsu H, Minamoto A, Mimura T, Shimada K, Yamashita H, Kiuchi Y
    • Journal Title

      Int Ophthalmol

      Volume: 29(3) Pages: 161-7

    • DOI

      DOI:10.1007/s10792-008-9216-4

    • Peer Reviewed
  • [Journal Article] Changes of conjunctivochalasis with age in ahospital-based study2009

    • Author(s)
      Mimura T, Yamagami S, Usui T, Funatsu H, Mimura Y, Noma H, Honda N, Amano S
    • Journal Title

      Am J Ophthalmol

      Volume: 147(1) Pages: 171-177

    • DOI

      DOI:10.1016/j.ajo.2008.07.010

    • Peer Reviewed
  • [Journal Article] Association between serum lipoprotein(a) level and progression of non-proliferativediabetic retinopathy in Type 2 diabetes2009

    • Author(s)
      Funatsu H, Shimizu E, Noma H, Mimura T, Hori S
    • Journal Title

      Acta Ophthalmol

      Volume: 87(5) Pages: 501-5

    • DOI

      DOI:10.1111/j.1755-3768.2008.01298.x

    • Peer Reviewed
  • [Journal Article] Macular microcirculation inhypertensive patients with and without branchretinal vein occlusion2009

    • Author(s)
      Noma H, Funatsu H, Sakata K, Harino S, Mimura T, Hori S
    • Journal Title

      Acta Ophthalmol

      Volume: 87(6) Pages: 638-42

    • DOI

      DOI:10.1111/j.1755-3768.2008.01318.x

    • Peer Reviewed
  • [Journal Article] Relationship betweenrefraction and allergic conjunctivitis2009

    • Author(s)
      Mimura T, Mimura Y, Arimoto A, Amano S, Yamagami S, Funatsu H, Usui T, Noma H, Honda N, Okamoto S
    • Journal Title

      Eye

      Volume: 23(1) Pages: 63-6

    • DOI

      DOI:10.1038/sj.eye.6702999

    • Peer Reviewed
  • [Journal Article] Relation between Total Tear IgE andSeverity of Acute Seasonal AllergicConjunctivitis

    • Author(s)
      Mimura T, Usui T, Yamagami S, Miyai T, Amano S
    • Journal Title

      Current Eye Research, in press

    • Peer Reviewed
  • [Journal Article] Bilateral eyelid erythema associatedwith false eyelash glue

    • Author(s)
      Mimura T
    • Journal Title

      Cutan Ocul Toxicol inpress

    • DOI

      DOI:10.3109/15569527.2012.681088

    • Peer Reviewed
  • [Journal Article] Relationship between total tear IgEand specific serum IgE in autumnal allergicconjunctivitis

    • Author(s)
      Mimura T, Usui T, Yamagami S, Miyai T, Amano S
    • Journal Title

      Corne

      Volume: (in press)

    • DOI

      DOI:10.1097/ICO.0b013e318253214b

    • Peer Reviewed
  • [Journal Article] Bilateral choroidaldetachment after cord blood stem celltransplantation in an adult patient with acutemyeloid leukemia

    • Author(s)
      Mimura T, Nakashizuka T, Kami J, Kohmura M, Sato S, Dou K, Mori M
    • Journal Title

      Int Ophthalmol in press

    • DOI

      DOI:10.1007/s10792-012-9539-z

    • Peer Reviewed
  • [Presentation] イムノキャップラピッドを用いた涙液中特異的IgEと皮膚プリックテストの比較2012

    • Author(s)
      三村達哉、山上聡、臼井智彦、宮井尊史、天野史郎
    • Organizer
      第116回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-05
  • [Presentation] 円錐角膜に対し非対称性放射状角膜切開術、角膜クロスリンキング術後経過観察を行った1例角膜カンファランス20122012

    • Author(s)
      杉本宏一郎、宮井尊史、外山琢、三村達哉、臼井智彦、山上聡、天野史郎
    • Organizer
      第36回日本角膜学会総会第28回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
  • [Presentation] 両眼性角膜輪部機能不全に対する自家培養結膜上皮シート移植の1症例角膜カンファランス20122012

    • Author(s)
      愛新覚羅維、三村達哉、臼井智彦、山上聡、天野史郎
    • Organizer
      第36回日本角膜学会総会第28回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
  • [Presentation] 線維柱帯切除術後の水疱性角膜症に対する角膜内皮移植術(DSAEK)の短期成績角膜カンファランス2012

    • Author(s)
      外山琢、宮井尊史、杉本宏一郎、三村達哉、臼井智彦、山上聡、天野史郎
    • Organizer
      第36回日本角膜学会総会第28回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
  • [Presentation] イムノキャップラピッドを用いた涙液中迅速特異的IgE抗体測定角膜カンファランス20122012

    • Author(s)
      堀田浩史、三村達哉、山上聡、臼井智彦、宮井尊史、天野史郎
    • Organizer
      第36回日本角膜学会総会第28回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
  • [Presentation] アレルギー性結膜炎患者における黄砂の影響角膜カンファランス20122012

    • Author(s)
      三村達哉、山上聡、臼井智彦、宮井尊史、天野史郎、藤島浩
    • Organizer
      第36回日本角膜学会総会第28回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
  • [Presentation] コンタクトレンズ装用による結膜弛緩症、瞼裂斑、および結膜下出血2011

    • Author(s)
      三村達哉
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
  • [Presentation] 感染性角膜炎に対する治療的角膜移植術の手術成績2011

    • Author(s)
      外山琢、臼井智彦、宮井尊史、三村達哉、山上聡、天野史郎
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
  • [Presentation] 網膜静脈分枝閉塞症に伴う黄斑浮腫におけるVEGF受容体と炎症関連分子との関連性2011

    • Author(s)
      野間英孝、船津英陽、三村達哉、堀貞夫
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
  • [Presentation] 骨髄移植後寛解状態の悪性リンパ腫に認めたHHV-6による網膜分離症、網膜炎の一例2011

    • Author(s)
      竇一博、中静隆之、西田彩、幸村百理男、上順子、三村達哉、岸本修一、佐藤新兵、森樹郎
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-07
  • [Presentation] 網膜静脈分枝閉塞症に伴う黄斑浮腫における術後の網膜感度と形態的検査との関連性2011

    • Author(s)
      野間英孝、船津英陽、張野正誉、三村達哉、堀貞夫
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
  • [Presentation] Relationship betweenPinguecula and Diabetes Mellitus2011

    • Author(s)
      Tatsuya Mimura, Mikiro Mori, TomohikoUsui, Shiro Amano
    • Organizer
      The Assosiation for Research in Vision and Ophthalmology Fort Lauderdale
    • Place of Presentation
      Florida, USA
    • Year and Date
      2011-05-01
  • [Presentation] 涙液中総IgE抗体価とアレルギー性結膜炎重症度の関係角膜カンファランス20112011

    • Author(s)
      保手濱充啓、三村達哉、森樹郎、臼井智彦、天野史郎
    • Organizer
      第35回日本角膜学会総会第27回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-17
  • [Presentation] 秋季アレルギー性結膜炎患者における涙液中特異的IgE角膜カンファランス20112011

    • Author(s)
      三村達哉、森樹郎、臼井智彦、天野史郎
    • Organizer
      第35回日本角膜学会総会第27回日本角膜移植学会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-17
  • [Presentation] Role of MT1-MMP onanti-angiogenic proteoglycan2010

    • Author(s)
      Tatsuya Mimura
    • Organizer
      Decorin, incorneal angiogenesis 16th Kyoto CorneaClub
    • Place of Presentation
      京都
    • Year and Date
      2010-12-03
  • [Presentation] 外来でできる涙液・アレルギー検査2010

    • Author(s)
      三村達哉
    • Organizer
      第1回虎門会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-24
  • [Presentation] 多種抗原測定キットを用いたアレルギー性結膜炎患者涙液中の特異的IgE2010

    • Author(s)
      三村達哉
    • Organizer
      第64回日本臨床眼科学会・専門別研究会オキュラーサーフェス研究会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-11
  • [Presentation] アマンタジン内服による両眼性・可逆性角膜浮腫の1症例2010

    • Author(s)
      保手濱充啓、三村達哉、臼井智彦、天野史郎、川島秀俊
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-11-11
  • [Presentation] Rapid measurement ofspecific tear IgE in allergic conjunctivitisusing immfast check J1 in spring2010

    • Author(s)
      Tatsuya Mimura, Tomohiko Usui, MikiroMori, Hideharu Funatsu, Hidetaka Noma, Shiro Amano
    • Organizer
      The Assosiation for Research in Vision and Ophthalmology Fort Lauderdale
    • Place of Presentation
      Florida, USA
    • Year and Date
      2010-05-02
  • [Presentation] 網膜静脈閉塞症に伴う黄斑浮腫と細胞接着因子との関連性2010

    • Author(s)
      野間英孝、船津英陽、針野正誉、三村達哉、堀貞夫
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-15
  • [Presentation] アレルギー性結膜炎患者における血清IgE抗体価と屈折の関係2010

    • Author(s)
      三村達哉、森樹郎、臼井智彦、天野史郎
    • Organizer
      第114回日本眼科学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-15
  • [Presentation] 結膜弛緩症と屈折第34回角膜カンファランス2010

    • Author(s)
      豊野哲也、三村達哉、臼井智彦、天野史郎
    • Organizer
      第26回日本角膜移植学会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2010-02-11
  • [Presentation] ラタノプロスト点眼によるマウス角膜MMPsの発現変化第34回角膜カンファランス2010

    • Author(s)
      本田紀彦、臼井智彦、宮井尊史、小島良平、宮田和典、三村達哉、相原一、新家眞、天野史郎
    • Organizer
      第26回日本角膜移植学会
    • Place of Presentation
      宮城県仙台市
    • Year and Date
      2010-02-11
  • [Presentation] 前眼部OCTを用いた全層角膜移植術後内皮面の観察2010

    • Author(s)
      福田玲奈、臼井智彦、三村達哉、富所敦男、天野史郎
    • Organizer
      第33回日本眼科手術学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-01-22
  • [Presentation] 多種抗原測定キットを用いたアレルギー性結膜炎患者涙液中の特異的IgE2009

    • Author(s)
      三村達哉、臼井智彦、本田紀彦、天野史郎
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
  • [Presentation] アレルウォッチ涙液中総IgEと血清中総IgEおよび特異的IgEとの相関2009

    • Author(s)
      山本裕樹、三村達哉、臼井智彦、本田紀彦、天野史郎
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
  • [Presentation] アレルウォッチを用いた涙液、唾液、鼻汁中の総IgE測定2009

    • Author(s)
      愛新覚羅維、三村達哉、臼井智彦、本田紀彦、天野史郎
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
  • [Presentation] 瞼裂斑の重症度分類2009

    • Author(s)
      竇一博、三村達哉、臼井智彦、本田紀彦、山本裕樹、天野史郎、小幡博人
    • Organizer
      第63回日本臨床眼科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-10-09
  • [Presentation] Yasuhiko Tabata Transplantation ofCorneal Stroma Reconstructed with Gelatinand Multipotent Precursor Cells fromHuman Corneal Stroma2009

    • Author(s)
      Tatsuya Mimura, Shiro Amano, TomohikoUsui, Seiichi Yokoo, Satoru Yamagami, YuKimura
    • Organizer
      TERMIS国際再生医療学会
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-08-31
  • [Presentation] 網膜中心静脈分枝閉塞症に伴う黄斑浮腫における前房水と硝子体サイトカイン濃度との関連性2009

    • Author(s)
      野間英孝、船津英陽、張野正誉、三村達哉、武田晴信、堀貞夫
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Presentation] in vivoでのMT1-MMPのDecorin分解による角膜血管新生誘導2009

    • Author(s)
      三村達哉、Chang Jin-Hong、小島隆司、御宮知達也、崎元暢、臼井智彦、天野史郎、Dimitri T. Azar
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Presentation] 結膜下出血の原因および部位2009

    • Author(s)
      堀田浩史、三村達哉、臼井智彦、本田紀彦、福岡詩麻、天野史郎
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Presentation] ヒト角膜輪部上皮前駆細胞の分化能の検討2009

    • Author(s)
      横尾誠一、臼井智彦、三村達哉、杉崎顕史、天野史郎、山上聡
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Presentation] 培養ヒト角膜内皮細胞を用いたウサギのDescemet strippingendothelial keratoplasty2009

    • Author(s)
      本田紀彦、三村達哉、臼井智彦、天野史郎、新家眞
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Presentation] コンタクトレンズと結膜弛緩症(Conjunctivochalasis : CCh)2009

    • Author(s)
      山本裕樹、三村達哉、臼井智彦、本田紀彦、福岡詩麻、天野史郎
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Presentation] 線維柱帯切除術前後の波面収差解析の比較2009

    • Author(s)
      福岡詩麻、三村達哉、本田紀彦、臼井智彦、天野史郎、新家眞
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
  • [Book] Transplantation of corneal stroma reconstructed with gelatin and multipotent precursor cells from corneal stroma. In : Daniel Eberli, editor. Regenerative Medicine and Tissue Engineering ; From Cells to Organs/Book2011

    • Author(s)
      Mimura T, Tabata Y, Amano S
    • Total Pages
      347-362
    • Publisher
      ISBN, Publisher

URL: 

Published: 2013-07-31   Modified: 2015-12-15  

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