2011 Fiscal Year Final Research Report
Identification of bone coupling factor
| Project/Area Number |
21659427
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAKASHIMA Tomoki 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (00346959)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔生化学 / 骨代謝学 |
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| Research Abstract |
Bone remodeling optimizes bone strength. Regulation of bone remodeling requires a tightly orchestrated interplay among osteoblasts(bone forming cells), osteoclasts(bone resorbing cells) in bone surface and osteocytes, which embedded into bone matrix. To identify the regulation/coupling factor of bone remodeling, we investigated a genome-wide screening, proteome analysis of these bone cells and in vivo analysis of gene targeting mice.
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[Journal Article] Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of Irf2 in trypsinogen 5 gene transcription2011
Author(s)
Hayashi H, Kohno T, Yasui K, MurotaH, Kimura T, Duncan GS, Nakashima T, Yamamoto K, Katayama I, Ma Y, Chua KJ, Suematsu T, Shimokawa I, Akira S, Kubo Y, Mak TW, Matsuyama T
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Journal Title
Proc Natl Acad Sci USA
Volume: 108
Pages: 18766-71
Peer Reviewed
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[Journal Article] Evidence for osteocyte regulation of bone homeostasis through RANKL expression2011
Author(s)
Nakashima T, Hayashi M, Fukunaga T, Kurata K, Oh-hora M, Feng JQ, Bonewald LF, Kodama T, Wutz A, Wagner EF, Josef M. Penninger JM and Takayanagi H
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Journal Title
Nat Med
Volume: 17
Pages: 1231-4
Peer Reviewed
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[Journal Article] Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation2010
Author(s)
Nishikawa K, Nakashima T, Takeda S, Isogai M, Hamada M, Kimura A, KodamaT, Yamaguchi A, Owen MJ, Takahashi S, and Takayanagi H
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Journal Title
J Clin Invest
Volume: 120
Pages: 3455-65
Peer Reviewed
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