2011 Fiscal Year Final Research Report
An experimental study for a novel gene therapy for the highly malignant tumor of salivary gland using nanobubbles and ultrasound
| Project/Area Number |
21659431
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IIKUBO Masahiro 東北大学, 大学院・歯学研究科, 講師 (80302157)
MORI Shiro 東北大学, 病院, 講師 (80230069)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
KOJIMA Ikuho 東北大学, 大学院・歯学研究科, 助教 (80447169)
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| Project Period (FY) |
2009 – 2011
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| Keywords | ナノバブル / 超音波 / 唾液腺 / 悪性腫腫瘍 / 遺伝子治療 |
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| Research Abstract |
The aim of the present study is to develop a novel diagnosis and gene therapy system for the highly malignant tumor of salivary gland using nanobubbles and ultrasound. In the present study, by using experimental tumor model, we developed a high-resolution diagnostic imaging system utilizing nanobubbles and high-frequency ultrasound image analysis equipment. In addition, we were able to present the possibility of a new gene therapy method by transfer of a plasmid DNA, which inhibited the tumor growth, by utilizing nanobubbles and ultrasound.
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Research Products
(51 results)
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[Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy2011
Author(s)
Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar, M Fukumoto, T Shimura, Y Ohtake M H, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
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Journal Title
Cell Death Dis (2011)
Volume: 2
DOI
Peer Reviewed
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[Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound2010
Author(s)
Kodama T, Aoi A, Watabnabe Y, Horie S, Kodama M, Li L, Chen R, Teramoto N, Morikawa H, Mori S, Fukumoto M
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Journal Title
Ultrasound Med Biol
Volume: 36(7)
Pages: 1196-1205
Peer Reviewed
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[Journal Article] Evaluating the Role of Rheumatoid Factors for the Development of Rheumatoid Arthritis in a Mouse Model with a Newly Established ELISA System2010
Author(s)
Tanaka Y, Komori H, Mori S, Soga Y, Tsubaki T, Terada M, Miyazaki T, Fujino T, Nakamura S, Kanno H, Sawasaki T, Endo Y, Nose M
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Journal Title
Tohoku J Exp Med
Volume: 220 (3)
Pages: 199-206
Peer Reviewed
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[Journal Article] Accuracy of Intra-oral Radiology, Multi-detector Herical CT and Limited Cone Beam CT for the Detevtion of Horizontal Tooth Root Fracture2009
Author(s)
Iikubo M, Kobayashi K, Mishima A, Shimoda S, Daimaruya T, Igarashi C, Imanaka M, Yuasa M, Sakamoto M, Sasano T
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Journal Title
Oral SWurg Oral Med Oral Pathol Oral Radiol Endod
Volume: 108
Pages: 70-74
Peer Reviewed
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[Presentation] 頭頸部癌遺伝子治療に向けたナノバブルと超音波によるNIS遺伝子導入と124I-PET イメージング2011
Author(s)
渡邊夕紀子, 森士朗, 堀江佐知子, サックスニコラ, 李麗, 李深偉, 柳下陽子, 高地崇, 船木善仁, 菊池洋平, 山崎浩道, 石井慶造, 阪本真弥, 宮下仁, 小玉哲也
Organizer
第35回日本頭頸部癌学会
Place of Presentation
名古屋
Year and Date
20110609-10
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[Presentation] 頭頸部癌所属リンパ節転移の診断・治療に向けたリンパ節腫大マウスを用いたリンパ節転移モデルの開発2011
Author(s)
李麗, 森士朗, 柳下陽子, サックスニコラ, 堀江佐知子, 渡邊夕紀子, 高地崇, 李深偉, 宮下仁, 森川秀広, 阪本真弥, 小玉哲也
Organizer
第35回日本頭頸部癌学会
Place of Presentation
名古屋
Year and Date
20110609-10
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[Presentation] Characteristics of acinic cell carcinoma of the parotid gland on MR imaging2011
Author(s)
Sakamoto M, Kojima I, Iikubo M, Yamamura MJ, Mugikura S, Takahashi S, Ogawa T, Shiga K, Watanabe M, Sasano T
Organizer
The 18th International Congress of Dento-Maxillo-Facial Radiology
Place of Presentation
Hiroshima, Japan
Year and Date
20110525-29
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[Presentation] MRI findings of parotid tumors : Basal cell adenoma VS basal cell adenocarcinoma2011
Author(s)
Kojima I, Sakamoto M, Iikubo M, Yamamura MJ, Mugikura S, Takahashi S, Ogawa T, Shiga K, Watanabe M, Sasano T
Organizer
The 18th International Congress of Dento-Maxillo-Facial Radiology
Place of Presentation
Hiroshima, Japan
Year and Date
20110525-29
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[Presentation] Mechanism of edematous changes in masseter muscle evoked by muscle pain2011
Author(s)
Iikubo M, Yamamura MJ, Li L, Sasaki M, Kojima I, Satoh-Kuriwada S, Shoji N, Sakamoto M, Kodama T, Sasano T
Organizer
The 18th International Congress of Dento-Maxillo-Facial Radiology
Place of Presentation
Hiroshima, Japan
Year and Date
20110525-29
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[Presentation] Longitudinal three-dementional noninvasive imaging analysis and quantification of anti-tumor effects of TNF-alpha gene for small tumor2010
Author(s)
Horie S, Watanabe Y, Yagishita Y, Sax N, Chen R, Li L, Kojima T, Morikawa H, Sakamoto M, Ono S, Mori S, Kodama T
Organizer
The World Molecular Imaging Congress
Place of Presentation
Kyoto, Japan
Year and Date
20100908-11
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[Presentation] Volumetric and angiogenetic imaging system by using nanobubbles and high-frequency ultrasound for evaluation of the antitumor effect by cisplatin2010
Author(s)
Yagishita Y, Takata Y, Ohki K, Miyashita H, Morikawa H, Sakamoto M, Mori S, Kawamura H , Kodama T
Organizer
The 5th International Symposium on Medical, Bio-and Nano-Electronics. Book of Abstract. 161-162
Place of Presentation
Sendai, Japan
Year and Date
20100224-25
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[Presentation] Four-dimensional high-frequency ultrasound imaging system for early detection of lymph node micro-metastasis2010
Author(s)
Li L, Horie S, Rui Chen, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T
Organizer
The 5th International Symposium on Medical, Bio-and Nano-Electronics. Book of Abstract. 157-158
Place of Presentation
Sendai, Japan
Year and Date
20100224-25
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[Presentation] Ultrasound molecular imaging of lymph node metastasis with nano/microbubbles2010
Author(s)
Li L, Chen R, Horie S, Watanabe Y, Baba T, Sax N, Sakamoto M, Mori S, Takahashi S, Kodama T
Organizer
International Symposium of AIDS and Tuberculosis (ISAT2010)
Place of Presentation
Sendai, Japan
Year and Date
20100113-14
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