2011 Fiscal Year Final Research Report
Analysis of microRNAs and their target genes associated with phenotypes of oral squamous cell carcinomas.
| Project/Area Number |
21659469
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SASABE Eri 高知大学, 教育研究部・医療学系, 助教 (40363288)
MORISHITA Keiko 高知大学, 教育研究部・医療学系, 助教 (10527584)
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| Project Period (FY) |
2009 – 2011
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| Keywords | 口腔扁平上皮癌 / マイクロRNA / 悪性形質 |
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| Research Abstract |
We investigated the expression of microRNAs in oral squamous cell carcinoma(OSCC) cell lines and normal oral keratinocytes by using microarray analysis and real time-PCR. It was demonstrated that the expression of 9 microRNAs was up-regulated and that of 13 microRNAs was down-regulated in OSCC cells compared with normal cells. We also revealed that miR-34a, one of down-regulated genes, acts as a tumor suppressor gene in OSCC cells and that the expression of the microRNA is down-regulated in OSCC tissues.
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