2013 Fiscal Year Final Research Report
Asystems-level understanding of gene networks for the development and evolution of the chordate body plan
| Project/Area Number |
21671004
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (S)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
基礎ゲノム科学
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
SATOU Yutaka 京都大学, 大学院・理学研究科, 准教授 (40314174)
|
|---|
| Project Period (FY) |
2009 – 2013
|
| Keywords | ホヤ / ゲノム / 遺伝子ネットワーク / 転写調節 / BMPシグナリング / Pinhead |
|---|
| Research Abstract |
The ascidian, Ciona intestinalis, belongs to the same phylum, Chordata, as vertebrates. We demonstrated that maternal information in eggs of the ascidian establishes five distinct initial states for gene networks. We analyzed the embryonic gene networks, which start from these five initial states. We found that a genetic circuit that could have been involved in emergence of vertebrate anterior placodes. We also identified Pinhead as a novel antagonist specific for Admp signaling molecule, which is used for establishment of the dorsoventral axis in animal embryos. Admp gene abuts on Pinhead gene in genomes from insects to vertebrates. We uncovered that this conserved genomic configuration is due to a novel DNA-loop mediated mechanism for transcriptional repression.
|
-
-
-
-
-
-
[Journal Article] Blood System Formation in the Urochordate Ciona intestinalis Requires the Variable Receptor vCRL12012
Author(s)
F. Sommer, S. Awazu, F. Anton-Erxleben, D. Jiang, A. V.Klimovich, B. V. Klimovich, M. P Samoilovich, Y. Satou, M. KrUss, C.Gelhaus, Y KUrn, T. C. Bosch, K. Khalturin
-
Journal Title
Mol Biol Evol
Volume: 29
Pages: 3081-3093
DOI
Peer Reviewed
-
-
-
-
-
[Journal Article] CIPRO 2.5 : Ciona intestinalis protein database, a unique integrated repository of large-scale omicsdata, bioinformatic analyses and curated annotation, with user rating and reviewing functionality2011
Author(s)
T. Endo, K. Ueno, K. Yonezawa, K. Mineta, K. Hotta, Y Satou, L. Yamada, M. Ogasawara, H. Takahashi, A. Nakajima, M. Nakachi, M. Nomura, J. Yaguchi, Y. Sasakura, C. Yamasaki, M. Sera, A. C. Yoshizawa, T. Imanishi, H. Taniguchi and K. Inaba
-
Journal Title
Nucleic Acids Res
Volume: 39
Pages: D807-814
DOI
Peer Reviewed
-
[Journal Article] The ANISEED database : digital representation, formalization, and elucidation of a chordate developmental program2010
Author(s)
O. Tassy, D. Dauga, F. Daian, D. Sobral, F. Robin, P. Khoueiry, D. Salgado, V Fox, D. Caillol, R. Schiappa, B. Laporte, A. Rios, G. Luxardi, T. Kusakabe, J. S. Joly, S. Darras, L. Christiaen, M. Contensin, H. Auger, C. Lamy, C. Hudson, U. Rothbacher, M. J. Gilchrist, K. W. Makabe, K. Hotta, S. Fujiwara, N. Satoh, Y Satou and P Lemaire
-
Journal Title
Genome Res
Volume: 20
Pages: 1459-1468
DOI
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Remarks] 平成24年8月24日 日本経済新聞
-
[Remarks] 平成24年8月24日 京都新聞
-
[Remarks] 平成24年8月24日 日刊工業新聞
-
[Remarks] 平成25年10月26日 京都新聞
-
[Remarks] 平成25年11月22日 日刊工業新聞
