2013 Fiscal Year Final Research Report
Development of Innovative Methods for Analyzing Biological Molecules in Living Cells Based on Protein Chemistry
| Project/Area Number |
21675001
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Analytical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OZAWA Takeaki 東京大学, 大学院・理学系研究科(理学部), 教授 (40302806)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEUCHI Masaki 東京大学, 理学系研究科, 助教 (00332271)
YOSHIMURA Hideaki 東京大学, 理学系研究科, 特任助教 (90464205)
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| Project Period (FY) |
2009 – 2013
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| Keywords | 可視化 / ナノバイオ / 光スイッチ / バイオテクノロジー / 酵素反応 |
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| Research Abstract |
Chemical understanding of biological process in living cells is an extremely important for the progress of science. This research project aimed to develop novel analytical methods for resolving complicate networks and function of biological molecules in living cells. We developed 1) molecular probes to visualize biological function in living cells, 2) methods to identify specific molecules in intracellular signaling, and 3) molecular probes to control a biological function with external light. The probes and imaging technologies will be useful for the analysis of biomolecules in the fields of basic biology and pharmacological science.
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