2013 Fiscal Year Final Research Report
Functional architectonics of glyco-biomaterials designed via cellulosic nano-assemblers
| Project/Area Number |
21678002
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| Research Category |
Grant-in-Aid for Young Scientists (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Wood science
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| Research Institution | Kyushu University |
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Principal Investigator |
KITAOKA Takuya 九州大学, 大学院・農学研究院, 教授 (90304766)
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| Project Period (FY) |
2009 – 2013
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| Keywords | 糖鎖 / 酵素反応 / 自己組織化膜 / ナノ構造 / 細胞培養 / バイオインターフェース |
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| Research Abstract |
Nonaqueous biocatalysis and vectorial sugar-chain immobilization techniques that we successfully developed in this project allowed to functionally design various glyco-biointerfaces with controlled nanostructures of bioactive oligosaccharides via cellulosic nano-assemblers obtained from wood. Cellular morphology, physiological activation and immunological responses through glyco-receptor mediated signaling strongly depended on the combination and nanostructures of plural oligosaccharides, eventually revealing the possibility of the direct stimulation to cultured cells in contact with the biointerfaces. A pioneering research "Glyco-nanoarchitectonics" will open up a new phase for research and developments of new-concept glyco-biomaterials in medical and cell engineering fields.
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