Development of an novel method for studying relationships between neural circuits and behaviors using optogenetic approaches.

2010 Fiscal Year Final Research Report

• Project/Area Number: 21680028
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neuroscience in general
• Research Institution: National Institute for Basic Biology
• Principal Investigator: HIYAMA Takeshi National Institute for Basic Biology, 統合神経生物学研究部門, 助教 (90360338)
• Project Period (FY): 2009 – 2010
• Keywords: 光活性化型チャンネル

Research Abstract

The purpose of this research is development of a new method for studying the relationship of neural circuit and behaviors using light-activated channels and pumps. We developed a new system for optical stimulation of free-moving animals with optical fiber coupled to lasers. Using this system and a transgenic mice expressing KikGR, a photomodulatable fluorescent protein, we estimated the size of illuminated area in free-moving mice.

Research Products

• [Journal Article] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia. (2010)
  • Author(s): Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
  • Journal Title: Neuron 66 Pages: 508-522
  • Peer Reviewed
• [Journal Article] Na_xに対する自己抗体の産生が本態性高Na血症の原因となる (2010)
  • Author(s): 檜山武史, 野田昌晴
  • Journal Title: 細胞工学 29(11) Pages: 1132-1138
• [Journal Article] Nax-deficient mice show normal vasopressin response to dehydration. (2010)
  • Author(s): Nagakura A, Hiyama TY, Noda M.
  • Journal Title: Neuroscience Letters 472 Pages: 161-165
  • Peer Reviewed
• [Journal Article] 化学受容から行動までの情報ハイウエイ-4 脳のナトリウムセンサー (2009)
  • Author(s): 檜山武史, 渡辺英治, 野田昌晴
  • Journal Title: 日本味と匂学会誌 16 Pages: 133-140
• [Presentation] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia (2010)
  • Author(s): Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
  • Organizer: BMB2010
  • Place of Presentation: 神戸コンベンションセンター(神戸市)
  • Year and Date: 2010-12-10
• [Presentation] 体液塩濃度の恒常性:脳で感じるNa濃度 (2010)
  • Author(s): 檜山武史
  • Organizer: 第7回コンビナトリアル・バイオエンジニアリング会議「感覚の不思議をはかるために」
  • Place of Presentation: 千里阪急ホテル(吹田市)
  • Year and Date: 2010-11-12
• [Presentation] Autoimmunity to the sodium-level sensor in the brain causes essential hypernatremia (2010)
  • Author(s): Hiyama TY, Matsuda S, Fujikawa A, Matsumoto M, Watanabe E, Kajiwara H, Niimura F, Noda M.
  • Organizer: Neuro2010
  • Place of Presentation: 神戸コンベンションセンター(神戸市)
  • Year and Date: 2010-09-04
• [Book] トランスポートソームの世界-膜輸送研究の源流から未来へ-(金井好克, 竹島浩, 森泰生, 久保義弘編)(その他の生体内センサーチャネル) (2010)
  • Author(s): 檜山武史, 野田昌晴
  • Total Pages: 95-103
  • Publisher: 京都廣川書店
• [Remarks] 新聞報道等
• [Remarks] 2010/05/27 日経産業新聞「原因不明「高ナトリウム血症」 免疫異常が関与基礎生物研など解明」
• [Remarks] 2010/05/27 日経プレスリリース「基礎生物学研究所、高ナトリウム血症の発症機構を解明原因不明だった高ナトリウム血症の発症機構を解明～脳の体液Naレベルセンサーに対する抗体が産生される自己免疫疾患だった～」
• [Remarks] Web報道
• [Remarks] 2010/06/17 Faculty of 1000 "Must Read Paper" by Angela Vincent (University of Oxford, UK)
• [Remarks] 2010/05/27 Neuron誌トップページ"Featured Case Study"