2011 Fiscal Year Final Research Report
Brain-spinal cord neural circuits controlling androgen-dependent mood disorder and male sexual function
| Project/Area Number |
21680031
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Keywords | アンドロゲン / 雄性性機能 / 気分障害 / 脊髄 / 脳-脊髄神経ネットワーク / 神経解剖 / ガストリン放出ペプチド / オキシトシン |
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| Research Abstract |
We recently reported a previously unknown peptidergic system within the lumbosacral spinal cord that uses gastrin-releasing peptide(GRP) to trigger erection and ejaculation in male rats. The identification of a male-specific neural system regulating sexual functions offers new avenues for potential therapeutic approaches to male reproductive dysfunction. Furthermore, this study demonstrated that the spinal GRP system appears to be a stress-vulnerable centre for male reproductive functions, which may provide new insight into a clinical target for the treatment of stress-related erectile dysfunction in men. More studies are needed at the molecular and behavioral levels to investigate the potential determinants of sexually dimorphic brain-spinal cord neural circuits and related clinical disorders in humans.
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Research Products
(41 results)
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[Journal Article] Induction of the arginine vasopressin-enhanced green fluorescent protein fusion trans-gene in the rat locus coeruleus2010
Author(s)
M. Todoroki, Y. Ueta, H. Fujihara, H. Otsubo, M. Shibata, H. Hashimoto, M. Kobayashi, H. Sakamoto, M. Kawata, G. Dayanithi, D. Murphy, H. Hiro, K. Takahashi, S. Nagata
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Journal Title
Stress
Volume: 13
Pages: 281-291
Peer Reviewed
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[Journal Article] Aldosterone. sensitive NTS neurons regulate sensitivity of the baroreceptor reflex in high-sodium loaded rats2010
Author(s)
T. Masuda, Y. Hirabara, Y. Nakamura, A. Chisyaki, M. Tsuruhisa, M. Miyakawa, K. Honda, R. Saito, H. Sakamoto, M. Kawata, Y. Takano
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Journal Title
Journal of Pharmacological Sciences
Volume: 112
Pages: 482-486
Peer Reviewed
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[Journal Article] Characterization of in vivo effects of platelet-rich plasma and biodegradable gelatin hydrogel microspheres on degenerated intervertebral discs2009
Author(s)
K. Sawamura, T. Ikeda, M. Nagae, S. Okamoto, Y. Mikami, H. Hase, K. Ikoma, T. Yamada, H. Sakamoto, K.-I. Matsuda, Y. Tabata, M. Kawata, T. Kubo
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Journal Title
Tissue Engineering
Volume: 15
Pages: 3719-27
Peer Reviewed
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